Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 433361..434015 Replicon chromosome
Accession NZ_CP095161
Organism Avibacterium paragallinarum strain ZJ-C

Toxin (Protein)


Gene name hicA Uniprot ID A0A0F5EPP6
Locus tag LNL76_RS02240 Protein ID WP_046099083.1
Coordinates 433833..434015 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0F5ERJ0
Locus tag LNL76_RS02235 Protein ID WP_046099082.1
Coordinates 433361..433780 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNL76_RS02205 428415..428921 + 507 WP_194743095.1 hypothetical protein -
LNL76_RS02210 428908..429981 + 1074 WP_194743096.1 DUF3383 family protein -
LNL76_RS02215 430033..430461 + 429 WP_194743097.1 DUF3277 family protein -
LNL76_RS02220 430461..430946 + 486 WP_194743098.1 hypothetical protein -
LNL76_RS02225 430982..431134 + 153 WP_017805951.1 hypothetical protein -
LNL76_RS02230 431131..433323 + 2193 WP_194743099.1 tape measure protein -
LNL76_RS02235 433361..433780 - 420 WP_046099082.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LNL76_RS02240 433833..434015 - 183 WP_046099083.1 type II toxin-antitoxin system HicA family toxin Toxin
LNL76_RS02245 434105..434683 + 579 WP_194743100.1 hypothetical protein -
LNL76_RS02250 434683..435015 + 333 WP_194743101.1 hypothetical protein -
LNL76_RS02255 434993..435958 + 966 WP_194743102.1 hypothetical protein -
LNL76_RS02260 435951..436622 + 672 WP_194743103.1 Gp138 family membrane-puncturing spike protein -
LNL76_RS02265 436619..436984 + 366 WP_194743104.1 hypothetical protein -
LNL76_RS02270 436977..438413 + 1437 WP_194743105.1 baseplate J/gp47 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 366675..448941 82266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-63)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6957.05 Da        Isoelectric Point: 10.3460

>T241601 WP_046099083.1 NZ_CP095161:c434015-433833 [Avibacterium paragallinarum]
MKYSEFLRYLLEQGCKVENTKRGSHRKVTLNGHQTVFPYHGSQEIGTGLVHKIKKDLNLK

Download         Length: 183 bp

>T241601 NZ_LT992492:c2396560-2395622 [Vibrio cholerae]
ATGGATAAAGATAGCCCATATTACAAACAGGTTTCCTTGCTCATAAGAATGCTTCCTGTGGTAGCAACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGATTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCAGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATAGTTGTATCAAGTCCGGTTGCGACGATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAAATAATGCCAGTTCAAGAGTCTGTTGAAGACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGTATGTTACTTGGCAGTGAAGGGATTTCGAGAGAGATTTTGGTGGGTTTTTTAACCTA
TACATTAAGTCACCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAGCCTCTGAATGAGAAATTTCAGGCAGAAT
TTGACGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCCTCTGTTAGGCCCATGATGTTAATTGAACTGCAAAAA
CATTTCACAGAAAGGGATCATGCTTTCCTTATGTCATTCAAAAGAGGGCAACCTGACTGGGCATTGTTTGACTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAATTGCAGAACATTAACAAATTGGCAAAGAATCAAGCAAAACACCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15815.31 Da        Isoelectric Point: 4.7276

>AT241601 WP_046099082.1 NZ_CP095161:c433780-433361 [Avibacterium paragallinarum]
MLRYPVELKADDNGTFLVTFPDIPEAASVGEDLESALLEAEEGLETALEFYFDDKRPIPLPSKPQEGQYTVPLSLLRSLK
VLLLNEMLAQGVRKAEMARRLDVHMPQIDRLLDFRYPSKIDFVEKAFKKLGREIHLAVS

Download         Length: 420 bp

>AT241601 NZ_LT992492:c2397344-2396553 [Vibrio cholerae]
ATGTCATCTAAAATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
CGTGAGCTACTCGTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTGAAGAAGCTTAGTTCTGGTGTGTACTATCGTCCAA
ATGCGCAGGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTGGATGTGCAATTGGGCGTTCCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTACAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCGAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGCGGAAACCATAAGCTTGAAG
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAGCTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGATGCGATTGGAAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCATAGATGAAACAAGAATTAAATTGGGGGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F5EPP6

Antitoxin

Source ID Structure
AlphaFold DB A0A0F5ERJ0

References