Detailed information of TA system TA241600

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 415817..416419
• Replicon: chromosome
• Accession: NZ_CP095161
• Organism: Avibacterium paragallinarum strain ZJ-C

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LNL76_RS02095
• Protein ID: WP_017807336.1
• Coordinates: 416243..416419 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LNL76_RS02090
• Protein ID: WP_194743128.1
• Coordinates: 415817..416221 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNL76_RS02055	411035..411787	+	753	WP_194743122.1	Rha family transcriptional regulator	-
LNL76_RS02060	411784..412635	+	852	WP_194743123.1	replication protein	-
LNL76_RS02065	412628..413467	+	840	WP_194743124.1	ATP-binding protein	-
LNL76_RS02070	413464..414057	+	594	WP_194743125.1	DNA N-6-adenine-methyltransferase	-
LNL76_RS02075	414047..414472	+	426	WP_194743126.1	recombination protein NinB	-
LNL76_RS02080	414581..414817	-	237	WP_103853789.1	hypothetical protein	-
LNL76_RS02085	414883..415536	-	654	WP_194743127.1	P22AR C-terminal domain-containing protein	-
LNL76_RS02090	415817..416221	-	405	WP_194743128.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LNL76_RS02095	416243..416419	-	177	WP_017807336.1	type II toxin-antitoxin system HicA family toxin	Toxin
LNL76_RS02100	416529..417119	+	591	WP_194743129.1	recombination protein NinG	-
LNL76_RS02105	417119..417523	+	405	WP_194743130.1	hypothetical protein	-
LNL76_RS02115	417796..418128	+	333	WP_130239092.1	phage holin, lambda family	-
LNL76_RS02120	418121..418528	+	408	WP_222593582.1	M15 family metallopeptidase	-
LNL76_RS02125	418485..418850	+	366	WP_226537730.1	DUF2570 family protein	-
LNL76_RS02130	418864..419031	+	168	WP_226537729.1	hypothetical protein	-
LNL76_RS02135	419015..419269	+	255	WP_194743084.1	hypothetical protein	-
LNL76_RS02140	419280..419810	+	531	WP_194743085.1	terminase small subunit	-
LNL76_RS02145	419788..421137	+	1350	WP_194743086.1	PBSX family phage terminase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	366675..448941	82266

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6714.77 Da
• Isoelectric Point: 10.6249

>T241600 WP_017807336.1 NZ_CP095161:c416419-416243 [Avibacterium paragallinarum]
VNSKQMIKLLKQDGWYLDSINGSHHHFEHHQKKGKVTVPHPRAELGHLEKLIRKQAGL

Nucleotide

• Length: 177 bp

>T241600 NZ_LT992491:c957238-956936 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACATCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTCATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14939.02 Da
• Isoelectric Point: 4.7447

>AT241600 WP_194743128.1 NZ_CP095161:c416221-415817 [Avibacterium paragallinarum]
MLYPIALEKVTDGYVVSVPDIPGCFSAGDTLEEAYNNVKQAITSHLELVVRDNEEVPLPTPLEEHKANPDYQSVDIFFGV
IDVDISHLLGKAERINITMPAYLIKRIDDFVATHPHYKSRSHFLASVSADKIMA

Nucleotide

• Length: 405 bp

>AT241600 NZ_LT992491:c957483-957226 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA