Detailed information of TA system TA241598

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-YefM
• Location: 79684..80394
• Replicon: chromosome
• Accession: NZ_CP095161
• Organism: Avibacterium paragallinarum strain ZJ-C

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LNL76_RS00365
• Protein ID: WP_110478604.1
• Coordinates: 79684..80103 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LNL76_RS00370
• Protein ID: WP_110478603.1
• Coordinates: 80119..80394 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNL76_RS00340	74708..75790	-	1083	WP_110478657.1	extracellular solute-binding protein	-
LNL76_RS00345	75814..76656	-	843	WP_039085670.1	ABC transporter permease	-
LNL76_RS00350	76653..77522	-	870	WP_039085672.1	ABC transporter permease	-
LNL76_RS00355	77519..78592	-	1074	WP_110478606.1	ABC transporter ATP-binding protein	-
LNL76_RS00360	78828..79652	+	825	WP_110478605.1	glycerophosphodiester phosphodiesterase family protein	-
LNL76_RS00365	79684..80103	-	420	WP_110478604.1	type II toxin-antitoxin system VapC family toxin	Toxin
LNL76_RS00370	80119..80394	-	276	WP_110478603.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LNL76_RS00375	80581..81216	-	636	WP_110478602.1	bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase	-
LNL76_RS00380	81227..82168	-	942	WP_110478601.1	sugar kinase	-
LNL76_RS00385	82328..83116	+	789	WP_110478600.1	DNA-binding transcriptional regulator KdgR	-
LNL76_RS00390	83166..83906	-	741	Protein_79	2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase KduD	-
LNL76_RS00395	84070..84396	-	327	WP_245148586.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15774.45 Da
• Isoelectric Point: 7.1333

>T241598 WP_110478604.1 NZ_CP095161:c80103-79684 [Avibacterium paragallinarum]
MYLLDTNIISELYKFRNGKINAGVKAWLAEILPSETAISCITLSEIQTGILLKARRDKTQAALLNEWFKQQIIPVYQQNT
LPITAEIALMAAELHIPNKMDINDAYIAATAKFHRLKLVTRNIKDFENCGIEIINPFLD

Nucleotide

• Length: 420 bp

>T241598 NZ_LT992491:c953756-953223 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGAGACTCATTTGACTGTGGTGAGCAAGAGCT
AAATACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACCATGGTTTTACCTAGTGCTCAAC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGACA
CAATTAGCAAAGAAACTACCGAGATATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATTCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGGGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10623.98 Da
• Isoelectric Point: 4.8483

>AT241598 WP_110478603.1 NZ_CP095161:c80394-80119 [Avibacterium paragallinarum]
MAITVTSKEFNQRASYVLKLSETQPVFITKWGKIVSVLSNYRDYRKTQSEPSFEELFGQPTPPVSDKDIEDFDQILTEIR
KNTHIREVELD

Nucleotide

• Length: 276 bp

>AT241598 NZ_LT992491:c954154-953753 [Vibrio cholerae]
ATGCGTTGCCAGCCCCTTAGGCGGGCGTTATATTCTCCCTCGTTCCGTAAACTTTCCGTACGCATTGAATGTGCTTTAAG
TTTGGTCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCC
TTGATGAAGAGCTCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGA
CTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGATGAGTTTAT
GGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGT
GA