Detailed information of TA system TA241578

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2575868..2576506
• Replicon: chromosome
• Accession: NZ_CP095155
• Organism: Escherichia coli strain Iso00041

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0A6TXU8
• Locus tag: MU410_RS12530
• Protein ID: WP_001447010.1
• Coordinates: 2576330..2576506 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MU410_RS12525
• Protein ID: WP_001270286.1
• Coordinates: 2575868..2576284 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MU410_RS12505 (2571020)	2571020..2571961	-	942	WP_001251304.1	ABC transporter permease	-
MU410_RS12510 (2571962)	2571962..2572975	-	1014	WP_000220396.1	ABC transporter ATP-binding protein	-
MU410_RS12515 (2572993)	2572993..2574138	-	1146	WP_000047424.1	ABC transporter substrate-binding protein	-
MU410_RS12520 (2574383)	2574383..2575789	-	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
MU410_RS12525 (2575868)	2575868..2576284	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
MU410_RS12530 (2576330)	2576330..2576506	-	177	WP_001447010.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
MU410_RS12535 (2576728)	2576728..2576958	+	231	WP_000494244.1	YncJ family protein	-
MU410_RS12540 (2577050)	2577050..2579011	-	1962	WP_001303492.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
MU410_RS12545 (2579084)	2579084..2579620	-	537	WP_000429155.1	DNA-binding transcriptional regulator SutR	-
MU410_RS12550 (2579712)	2579712..2580887	+	1176	WP_001236265.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6779.86 Da
• Isoelectric Point: 11.2298

>T241578 WP_001447010.1 NZ_CP095155:c2576506-2576330 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T241578 NZ_LT992489:424897-425214 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT241578 WP_001270286.1 NZ_CP095155:c2576284-2575868 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT241578 NZ_LT992489:424636-424878 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Structures

Toxin

• AlphaFold DB: A0A0A6TXU8