241564

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 872235..872889 Replicon chromosome
Accession NZ_CP095155
Organism Escherichia coli strain Iso00041

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag MU410_RS04295 Protein ID WP_000244781.1
Coordinates 872482..872889 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag MU410_RS04290 Protein ID WP_000354046.1
Coordinates 872235..872501 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU410_RS04270 (868323) 868323..869756 - 1434 WP_001521235.1 6-phospho-beta-glucosidase BglA -
MU410_RS04275 (869801) 869801..870112 + 312 WP_001182949.1 N(4)-acetylcytidine aminohydrolase -
MU410_RS04280 (870276) 870276..870935 + 660 WP_000250269.1 hemolysin III family protein -
MU410_RS04285 (871012) 871012..871992 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
MU410_RS04290 (872235) 872235..872501 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
MU410_RS04295 (872482) 872482..872889 + 408 WP_000244781.1 protein YgfX Toxin
MU410_RS04300 (872929) 872929..873450 - 522 WP_001521233.1 flavodoxin FldB -
MU410_RS04305 (873562) 873562..874458 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
MU410_RS04310 (874483) 874483..875193 + 711 WP_001521231.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MU410_RS04315 (875199) 875199..876932 + 1734 WP_021523238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T241564 WP_000244781.1 NZ_CP095155:872482-872889 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T241564 NZ_LT992487:975832-976149 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT241564 WP_000354046.1 NZ_CP095155:872235-872501 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT241564 NZ_LT992487:975571-975813 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References