Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4785346..4786037 Replicon chromosome
Accession NZ_CP095150
Organism Klebsiella pneumoniae strain Iso00073

Toxin (Protein)


Gene name ykfI Uniprot ID A0A483YFJ1
Locus tag MU411_RS23370 Protein ID WP_025987721.1
Coordinates 4785346..4785687 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A2A5MHA6
Locus tag MU411_RS23375 Protein ID WP_019725272.1
Coordinates 4785711..4786037 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU411_RS23355 4782263..4783498 - 1236 WP_124044824.1 hypothetical protein -
MU411_RS23360 4784000..4784371 - 372 WP_223369725.1 hypothetical protein -
MU411_RS23365 4784398..4785231 - 834 WP_025987720.1 DUF4942 domain-containing protein -
MU411_RS23370 4785346..4785687 - 342 WP_025987721.1 TA system toxin CbtA family protein Toxin
MU411_RS23375 4785711..4786037 - 327 WP_019725272.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MU411_RS23380 4786051..4786527 - 477 WP_019725273.1 DNA repair protein RadC -
MU411_RS23385 4786537..4786983 - 447 WP_025987722.1 antirestriction protein -
MU411_RS23390 4787195..4787884 - 690 WP_009309812.1 hypothetical protein -
MU411_RS23395 4788449..4789339 - 891 WP_019725276.1 YfjP family GTPase -
MU411_RS23400 4789422..4790510 - 1089 WP_019725277.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4767713..4807186 39473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12867.90 Da        Isoelectric Point: 8.5195

>T241554 WP_025987721.1 NZ_CP095150:c4785687-4785346 [Klebsiella pneumoniae]
MKTLPATIQRAAKPCPSPVTVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQATGLLRQRHLPSIR

Download         Length: 342 bp

>T241554 NZ_LT992487:c913047-912760 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12276.01 Da        Isoelectric Point: 6.9560

>AT241554 WP_019725272.1 NZ_CP095150:c4786037-4785711 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFGDAECLKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR

Download         Length: 327 bp

>AT241554 NZ_LT992487:c913288-913037 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YFJ1

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MHA6

References