Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4873968..4875649 Replicon chromosome
Accession NZ_CP095145
Organism Klebsiella pneumoniae strain Iso00100

Toxin (Protein)


Gene name mosT Uniprot ID A0A486TL08
Locus tag MU412_RS23850 Protein ID WP_032417722.1
Coordinates 4873968..4874885 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag MU412_RS23855 Protein ID WP_004177809.1
Coordinates 4874891..4875649 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU412_RS23830 (4869274) 4869274..4870794 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
MU412_RS23835 (4870791) 4870791..4871789 + 999 WP_032417724.1 COG4158 family protein -
MU412_RS23840 (4871820) 4871820..4872761 + 942 WP_032417723.1 ABC transporter substrate-binding protein -
MU412_RS23845 (4872836) 4872836..4873843 + 1008 WP_004178300.1 carbohydrate kinase family protein -
MU412_RS23850 (4873968) 4873968..4874885 - 918 WP_032417722.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
MU412_RS23855 (4874891) 4874891..4875649 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
MU412_RS23860 (4875735) 4875735..4876463 - 729 WP_004177810.1 response regulator transcription factor -
MU412_RS23865 (4876736) 4876736..4878883 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
MU412_RS23870 (4879113) 4879113..4879799 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34674.07 Da        Isoelectric Point: 5.4707

>T241534 WP_032417722.1 NZ_CP095145:c4874885-4873968 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPQESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T241534 NZ_LT992476:2197248-2197436 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT241534 WP_004177809.1 NZ_CP095145:c4875649-4874891 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT241534 NZ_LT992476:2196960-2197220 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486TL08

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References