Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4694074..4694590 Replicon chromosome
Accession NZ_CP095145
Organism Klebsiella pneumoniae strain Iso00100

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag MU412_RS22915 Protein ID WP_009309309.1
Coordinates 4694074..4694358 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MU412_RS22920 Protein ID WP_002886901.1
Coordinates 4694348..4694590 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU412_RS22890 (4689557) 4689557..4689820 - 264 WP_025987940.1 PTS sugar transporter subunit IIB -
MU412_RS22895 (4689950) 4689950..4690123 + 174 WP_019725541.1 hypothetical protein -
MU412_RS22900 (4690126) 4690126..4690869 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MU412_RS22905 (4691226) 4691226..4693364 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MU412_RS22910 (4693606) 4693606..4694070 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MU412_RS22915 (4694074) 4694074..4694358 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU412_RS22920 (4694348) 4694348..4694590 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MU412_RS22925 (4694668) 4694668..4696578 - 1911 WP_004152270.1 PRD domain-containing protein -
MU412_RS22930 (4696601) 4696601..4697755 - 1155 WP_002886900.1 lactonase family protein -
MU412_RS22935 (4697822) 4697822..4698562 - 741 WP_032417761.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T241533 WP_009309309.1 NZ_CP095145:c4694358-4694074 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T241533 NZ_LT992476:c1999703-1999596 [Staphylococcus aureus]
GTGATATCTATTGCAAATGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT241533 WP_002886901.1 NZ_CP095145:c4694590-4694348 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT241533 NZ_LT992476:1999506-1999543 [Staphylococcus aureus]
AACATGTCGCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References