Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4006069..4006688 Replicon chromosome
Accession NZ_CP095145
Organism Klebsiella pneumoniae strain Iso00100

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MU412_RS19645 Protein ID WP_002892050.1
Coordinates 4006470..4006688 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MU412_RS19640 Protein ID WP_002892066.1
Coordinates 4006069..4006443 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU412_RS19630 (4001221) 4001221..4002414 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MU412_RS19635 (4002437) 4002437..4005583 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
MU412_RS19640 (4006069) 4006069..4006443 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MU412_RS19645 (4006470) 4006470..4006688 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MU412_RS19650 (4006847) 4006847..4007413 + 567 WP_002892030.1 maltose O-acetyltransferase -
MU412_RS19655 (4007385) 4007385..4007525 - 141 WP_004147370.1 hypothetical protein -
MU412_RS19660 (4007546) 4007546..4008016 + 471 WP_002892026.1 YlaC family protein -
MU412_RS19665 (4007991) 4007991..4009442 - 1452 WP_096903163.1 PLP-dependent aminotransferase family protein -
MU412_RS19670 (4009543) 4009543..4010241 + 699 WP_032416783.1 GNAT family protein -
MU412_RS19675 (4010238) 4010238..4010378 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MU412_RS19680 (4010378) 4010378..4010641 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T241531 WP_002892050.1 NZ_CP095145:4006470-4006688 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T241531 NZ_LT992476:951695-952057 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT241531 WP_002892066.1 NZ_CP095145:4006069-4006443 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT241531 NZ_LT992476:951528-951698 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References