Detailed information of TA system TA241530

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2617310..2618898
• Replicon: chromosome
• Accession: NZ_CP095145
• Organism: Klebsiella pneumoniae strain Iso00100

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A6T928
• Locus tag: MU412_RS12875
• Protein ID: WP_004176197.1
• Coordinates: 2617310..2618632 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MU412_RS12880
• Protein ID: WP_032417111.1
• Coordinates: 2618632..2618898 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MU412_RS12860 (2612366)	2612366..2614867	+	2502	WP_016831617.1	fimbria/pilus outer membrane usher protein	-
MU412_RS12865 (2614855)	2614855..2615859	+	1005	WP_004176196.1	fimbrial protein	-
MU412_RS12870 (2616001)	2616001..2617293	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
MU412_RS12875 (2617310)	2617310..2618632	-	1323	WP_004176197.1	type II toxin-antitoxin system HipA family toxin	Toxin
MU412_RS12880 (2618632)	2618632..2618898	-	267	WP_032417111.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MU412_RS12885 (2619163)	2619163..2619489	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
MU412_RS12890 (2619486)	2619486..2619986	-	501	WP_002904787.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
MU412_RS12895 (2619964)	2619964..2621343	-	1380	WP_021440115.1	nucleobase:cation symporter-2 family protein	-
MU412_RS12900 (2621689)	2621689..2622843	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
MU412_RS12905 (2622824)	2622824..2623747	-	924	WP_096903034.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	mgtC / iroE	2422169..2653742	231573

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49111.41 Da
• Isoelectric Point: 7.5357

>T241530 WP_004176197.1 NZ_CP095145:c2618632-2617310 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T241530 NZ_LT992476:932111-932320 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9926.32 Da
• Isoelectric Point: 8.5912

>AT241530 WP_032417111.1 NZ_CP095145:c2618898-2618632 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETASAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT241530 NZ_LT992476:931806-932099 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Toxin

• AlphaFold DB: A6T928