Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 799377..800034 Replicon chromosome
Accession NZ_CP095145
Organism Klebsiella pneumoniae strain Iso00100

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MU412_RS03980 Protein ID WP_002916310.1
Coordinates 799624..800034 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag MU412_RS03975 Protein ID WP_245133864.1
Coordinates 799377..799643 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU412_RS03950 (794687) 794687..796120 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
MU412_RS03955 (796239) 796239..796865 - 627 WP_065518996.1 MurR/RpiR family transcriptional regulator -
MU412_RS03960 (796915) 796915..797226 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
MU412_RS03965 (797390) 797390..798049 + 660 WP_002916317.1 hemolysin III family protein -
MU412_RS03970 (798148) 798148..799131 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MU412_RS03975 (799377) 799377..799643 + 267 WP_245133864.1 FAD assembly factor SdhE Antitoxin
MU412_RS03980 (799624) 799624..800034 + 411 WP_002916310.1 protein YgfX Toxin
MU412_RS03985 (800041) 800041..800562 - 522 WP_002916308.1 flavodoxin FldB -
MU412_RS03990 (800663) 800663..801559 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MU412_RS03995 (801582) 801582..802295 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MU412_RS04000 (802301) 802301..804034 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T241521 WP_002916310.1 NZ_CP095145:799624-800034 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T241521 NZ_LT992475:c1361873-1361766 [Staphylococcus aureus]
GTGATATCTATTGCAAATGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10422.95 Da        Isoelectric Point: 5.6907

>AT241521 WP_245133864.1 NZ_CP095145:799377-799643 [Klebsiella pneumoniae]
MGINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT241521 NZ_LT992475:1361676-1361713 [Staphylococcus aureus]
AACATGTCGCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure

References