Detailed information of TA system TA241515

Bioinformatically predicted

Overview

TA module

• Type: III
• Classification (family/domain): toxIN/ToxN(toxin)
• Location: 3552..4204
• Replicon: plasmid pIso00199_03
• Accession: NZ_CP095143
• Organism: Klebsiella pneumoniae strain Iso00199

Toxin (Protein)

• Gene name: toxN
• Uniprot ID: -
• Locus tag: MU413_RS27940
• Protein ID: WP_105720466.1
• Coordinates: 3552..4067 (-)
• Length: 172 a.a.

Antitoxin (RNA)

Gene name	toxI
Locus tag	-
Coordinates	4069..4204 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
- (1)	1..44	-	44	NuclAT_6	-	-
- (1)	1..44	-	44	NuclAT_6	-	-
- (1)	1..44	-	44	NuclAT_6	-	-
- (1)	1..44	-	44	NuclAT_6	-	-
- (1)	1..45	-	45	NuclAT_10	-	-
- (1)	1..45	-	45	NuclAT_10	-	-
- (1)	1..45	-	45	NuclAT_10	-	-
- (1)	1..45	-	45	NuclAT_10	-	-
- (1)	1..48	-	48	NuclAT_7	-	-
- (1)	1..48	-	48	NuclAT_7	-	-
- (1)	1..48	-	48	NuclAT_7	-	-
- (1)	1..48	-	48	NuclAT_7	-	-
- (1)	1..48	-	48	NuclAT_8	-	-
- (1)	1..48	-	48	NuclAT_8	-	-
- (1)	1..48	-	48	NuclAT_8	-	-
- (1)	1..48	-	48	NuclAT_8	-	-
- (1)	1..48	-	48	NuclAT_9	-	-
- (1)	1..48	-	48	NuclAT_9	-	-
- (1)	1..48	-	48	NuclAT_9	-	-
- (1)	1..48	-	48	NuclAT_9	-	-
MU413_RS27925 (1638)	1638..1919	-	282	WP_105720469.1	hypothetical protein	-
MU413_RS27930 (1929)	1929..2186	-	258	WP_105720468.1	hypothetical protein	-
MU413_RS27935 (2731)	2731..3441	+	711	WP_105720467.1	hypothetical protein	-
MU413_RS27940 (3552)	3552..4067	-	516	WP_105720466.1	type III toxin-antitoxin system ToxN/AbiQ family toxin	Toxin
- (4119)	4119..4176	-	58	NuclAT_4	-	-
- (4119)	4119..4176	-	58	NuclAT_4	-	-
- (4119)	4119..4176	-	58	NuclAT_4	-	-
- (4119)	4119..4176	-	58	NuclAT_4	-	-
- (4069)	4069..4204	-	136	NuclAT_0	-	Antitoxin
- (4069)	4069..4204	-	136	NuclAT_0	-	Antitoxin
- (4069)	4069..4204	-	136	NuclAT_0	-	Antitoxin
- (4069)	4069..4204	-	136	NuclAT_0	-	Antitoxin
- (4119)	4119..4204	-	86	NuclAT_1	-	-
- (4119)	4119..4204	-	86	NuclAT_1	-	-
- (4119)	4119..4204	-	86	NuclAT_1	-	-
- (4119)	4119..4204	-	86	NuclAT_1	-	-
- (4119)	4119..4204	-	86	NuclAT_2	-	-
- (4119)	4119..4204	-	86	NuclAT_2	-	-
- (4119)	4119..4204	-	86	NuclAT_2	-	-
- (4119)	4119..4204	-	86	NuclAT_2	-	-
- (4119)	4119..4204	-	86	NuclAT_3	-	-
- (4119)	4119..4204	-	86	NuclAT_3	-	-
- (4119)	4119..4204	-	86	NuclAT_3	-	-
- (4119)	4119..4204	-	86	NuclAT_3	-	-
- (4155)	4155..4204	-	50	NuclAT_5	-	-
- (4155)	4155..4204	-	50	NuclAT_5	-	-
- (4155)	4155..4204	-	50	NuclAT_5	-	-
- (4155)	4155..4204	-	50	NuclAT_5	-	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..4204	4204

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• ToxN/AbiQ toxin (1-159)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19758.74 Da
• Isoelectric Point: 6.2510

>T241515 WP_105720466.1 NZ_CP095143:c4067-3552 [Klebsiella pneumoniae]
MKFYTISSSYIRYLKGFDDKVPNSEDPTYNNPKAFIGIVLEIEGHKYLAPLTSPKAWHANVKESSPAFFKLHENGVPDNQ
LGLINLKFMIPIIEAEVSLLDLDSMPNTPYKRMLYKQLQFIRVNEDKISEKSKLLRNLALQGRMQGTCDFAVLEEKYQYF
GKKPEDMEIDD

Nucleotide

• Length: 516 bp

>T241515 NZ_LT992474:c2823750-2823646 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTAGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 136 bp

>AT241515 NZ_CP095143:c4204-4069 [Klebsiella pneumoniae]
TGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTCATTTACTACCT
TAAAGTAATAAAGTAAAAAAGGCGACTATACACAGTCGCCTTTTTTACGAGAAAAA

Structures

Antitoxin