Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4799123..4799639 Replicon chromosome
Accession NZ_CP095140
Organism Klebsiella pneumoniae strain Iso00199

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag MU413_RS23815 Protein ID WP_002886902.1
Coordinates 4799123..4799407 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MU413_RS23820 Protein ID WP_002886901.1
Coordinates 4799397..4799639 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU413_RS23790 (4794539) 4794539..4794802 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
MU413_RS23795 (4794932) 4794932..4795105 + 174 WP_032410138.1 hypothetical protein -
MU413_RS23800 (4795108) 4795108..4795851 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
MU413_RS23805 (4796208) 4796208..4798346 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MU413_RS23810 (4798655) 4798655..4799119 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MU413_RS23815 (4799123) 4799123..4799407 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU413_RS23820 (4799397) 4799397..4799639 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MU413_RS23825 (4799717) 4799717..4801627 - 1911 WP_009486549.1 PRD domain-containing protein -
MU413_RS23830 (4801650) 4801650..4802804 - 1155 WP_023302389.1 lactonase family protein -
MU413_RS23835 (4802871) 4802871..4803611 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T241511 WP_002886902.1 NZ_CP095140:c4799407-4799123 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T241511 NZ_LT992474:c2541290-2541138 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT241511 WP_002886901.1 NZ_CP095140:c4799639-4799397 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT241511 NZ_LT992474:c2541914-2541315 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAACAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References