Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4725802..4726612 Replicon chromosome
Accession NZ_CP095140
Organism Klebsiella pneumoniae strain Iso00199

Toxin (Protein)


Gene name KacT Uniprot ID A0A332NV98
Locus tag MU413_RS23485 Protein ID WP_014908042.1
Coordinates 4725802..4726335 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag MU413_RS23490 Protein ID WP_023343051.1
Coordinates 4726346..4726612 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU413_RS23480 (4724633) 4724633..4725754 + 1122 WP_012737335.1 cupin domain-containing protein -
MU413_RS23485 (4725802) 4725802..4726335 - 534 WP_014908042.1 type II toxin-antitoxin system toxin KacT Toxin
MU413_RS23490 (4726346) 4726346..4726612 - 267 WP_023343051.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
MU413_RS23495 (4726715) 4726715..4728148 - 1434 WP_023343050.1 Cu(+)/Ag(+) sensor histidine kinase -
MU413_RS23500 (4728138) 4728138..4728821 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
MU413_RS23505 (4728994) 4728994..4730379 + 1386 WP_024623207.1 efflux transporter outer membrane subunit -
MU413_RS23510 (4730397) 4730397..4730741 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19795.68 Da        Isoelectric Point: 5.2614

>T241510 WP_014908042.1 NZ_CP095140:c4726335-4725802 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T241510 NZ_LT992474:1655038-1655145 [Staphylococcus aureus]
GTGATATCTATTGCAAATGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10021.46 Da        Isoelectric Point: 10.5807

>AT241510 WP_023343051.1 NZ_CP095140:c4726612-4726346 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRRVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT241510 NZ_LT992474:c1655254-1655140 [Staphylococcus aureus]
TAAAAAGACGACATGCAGTAACATGTCGCCTAATGAGCCCGTTAAAAAGACGGTGACTAAATGAGATTTGCTTTAACCAT
CATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332NV98

Antitoxin

Source ID Structure

References