Detailed information of TA system TA241495

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4414570..4415404
• Replicon: chromosome
• Accession: NZ_CP095137
• Organism: Escherichia coli strain Iso00225

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: MU414_RS21615
• Protein ID: WP_001546109.1
• Coordinates: 4415027..4415404 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: MU414_RS21610
• Protein ID: WP_001545732.1
• Coordinates: 4414570..4414950 (+)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MU414_RS21575 (4410856)	4410856..4411311	+	456	WP_001545736.1	IrmA family protein	-
MU414_RS21580 (4411390)	4411390..4411545	+	156	WP_001119723.1	DUF905 family protein	-
MU414_RS21585 (4411723)	4411723..4412541	+	819	WP_001545735.1	DUF932 domain-containing protein	-
MU414_RS21590 (4412596)	4412596..4413081	+	486	WP_000849588.1	antirestriction protein	-
MU414_RS21595 (4413097)	4413097..4413573	+	477	WP_001545734.1	RadC family protein	-
MU414_RS21600 (4413636)	4413636..4413857	+	222	WP_000692353.1	DUF987 domain-containing protein	-
MU414_RS21605 (4413876)	4413876..4414520	+	645	WP_001545733.1	hypothetical protein	-
MU414_RS21610 (4414570)	4414570..4414950	+	381	WP_001545732.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MU414_RS21615 (4415027)	4415027..4415404	+	378	WP_001546109.1	TA system toxin CbtA family protein	Toxin
MU414_RS21620 (4415401)	4415401..4415889	+	489	WP_000761698.1	DUF5983 family protein	-
MU414_RS21625 (4415906)	4415906..4416094	+	189	WP_001545730.1	DUF957 domain-containing protein	-
MU414_RS21630 (4416179)	4416179..4417026	+	848	Protein_4245	DUF4942 domain-containing protein	-
MU414_RS21635 (4417298)	4417298..4417948	-	651	WP_000056749.1	3-keto-L-gulonate-6-phosphate decarboxylase UlaD	-
MU414_RS21640 (4417962)	4417962..4418426	-	465	WP_000776505.1	PTS ascorbate transporter subunit IIA	-
MU414_RS21645 (4418436)	4418436..4418741	-	306	WP_000218362.1	PTS ascorbate transporter subunit IIB	-
MU414_RS21650 (4418757)	4418757..4420154	-	1398	WP_000404886.1	PTS ascorbate transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13986.00 Da
• Isoelectric Point: 8.5190

>T241495 WP_001546109.1 NZ_CP095137:4415027-4415404 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYKMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T241495 NZ_LT992472:1680343-1680519 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13994.73 Da
• Isoelectric Point: 5.0696

>AT241495 WP_001545732.1 NZ_CP095137:4414570-4414950 [Escherichia coli]
VSDTLSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFNNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT241495 NZ_LT992472:c1680681-1680507 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG