Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1984040..1984871 Replicon chromosome
Accession NZ_CP095137
Organism Escherichia coli strain Iso00225

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag MU414_RS09445 Protein ID WP_000854814.1
Coordinates 1984040..1984414 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A641DSP2
Locus tag MU414_RS09450 Protein ID WP_001546021.1
Coordinates 1984503..1984871 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU414_RS09410 (1980035) 1980035..1980364 + 330 WP_000450409.1 DUF496 family protein -
MU414_RS09415 (1980465) 1980465..1980788 - 324 WP_223216378.1 EutP/PduV family microcompartment system protein -
MU414_RS09420 (1980767) 1980767..1980847 + 81 WP_023441679.1 hypothetical protein -
MU414_RS09425 (1981058) 1981058..1982599 + 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
MU414_RS09430 (1982614) 1982614..1983360 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
MU414_RS09435 (1983723) 1983723..1983803 - 81 Protein_1854 hypothetical protein -
MU414_RS09440 (1983849) 1983849..1984043 - 195 WP_000988601.1 DUF5983 family protein -
MU414_RS09445 (1984040) 1984040..1984414 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
MU414_RS09450 (1984503) 1984503..1984871 - 369 WP_001546021.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
MU414_RS09455 (1984951) 1984951..1985172 - 222 WP_000692323.1 DUF987 domain-containing protein -
MU414_RS09460 (1985235) 1985235..1985711 - 477 WP_001610726.1 RadC family protein -
MU414_RS09465 (1985727) 1985727..1986200 - 474 WP_001385393.1 antirestriction protein -
MU414_RS09470 (1986463) 1986463..1987284 - 822 WP_213848171.1 DUF932 domain-containing protein -
MU414_RS09475 (1987505) 1987505..1987915 - 411 WP_000846704.1 hypothetical protein -
MU414_RS09480 (1987931) 1987931..1988608 - 678 WP_001362823.1 hypothetical protein -
MU414_RS09485 (1988744) 1988744..1989814 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T241479 WP_000854814.1 NZ_CP095137:c1984414-1984040 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T241479 NZ_LT992470:2708993-2709145 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13607.47 Da        Isoelectric Point: 6.3139

>AT241479 WP_001546021.1 NZ_CP095137:c1984871-1984503 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGLFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT241479 NZ_LT992470:2708369-2708968 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAACAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A641DSP2

References