Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 45982..46780 Replicon chromosome
Accession NZ_CP095137
Organism Escherichia coli strain Iso00225

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag MU414_RS00240 Protein ID WP_000854735.1
Coordinates 45982..46359 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag MU414_RS00245 Protein ID WP_001285415.1
Coordinates 46406..46780 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU414_RS00210 (41327) 41327..42145 + 819 WP_000779409.1 lipoprotein NlpA -
MU414_RS00215 (42149) 42149..43072 - 924 WP_000535950.1 carboxylate/amino acid/amine transporter -
MU414_RS00220 (43250) 43250..43747 - 498 WP_000509815.1 hypothetical protein -
MU414_RS00225 (44343) 44343..45185 - 843 WP_000036706.1 DUF4942 domain-containing protein -
MU414_RS00230 (45282) 45282..45479 - 198 WP_000839266.1 DUF957 domain-containing protein -
MU414_RS00235 (45497) 45497..45985 - 489 WP_000761680.1 DUF5983 family protein -
MU414_RS00240 (45982) 45982..46359 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
MU414_RS00245 (46406) 46406..46780 - 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MU414_RS00250 (46860) 46860..47081 - 222 WP_000692309.1 DUF987 domain-containing protein -
MU414_RS00255 (47144) 47144..47620 - 477 WP_001366855.1 RadC family protein -
MU414_RS00260 (47636) 47636..48115 - 480 WP_042630954.1 antirestriction protein -
MU414_RS00265 (48197) 48197..49015 - 819 WP_001175149.1 DUF932 domain-containing protein -
MU414_RS00270 (49105) 49105..49338 - 234 WP_001278287.1 DUF905 family protein -
MU414_RS00275 (49344) 49344..50021 - 678 WP_001097301.1 hypothetical protein -
MU414_RS00280 (50169) 50169..50849 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T241471 WP_000854735.1 NZ_CP095137:c46359-45982 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T241471 NZ_LT992470:c752000-751893 [Staphylococcus aureus]
GTGATATCTATTGCAAATGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT241471 WP_001285415.1 NZ_CP095137:c46780-46406 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT241471 NZ_LT992470:751803-751840 [Staphylococcus aureus]
AACATGTCGCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References