Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4892545..4893061 Replicon chromosome
Accession NZ_CP095132
Organism Klebsiella pneumoniae strain Iso00267

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag MU415_RS23865 Protein ID WP_009486548.1
Coordinates 4892545..4892829 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MU415_RS23870 Protein ID WP_002886901.1
Coordinates 4892819..4893061 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU415_RS23840 (4887941) 4887941..4888204 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
MU415_RS23845 (4888334) 4888334..4888507 + 174 WP_004222159.1 hypothetical protein -
MU415_RS23850 (4888510) 4888510..4889253 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MU415_RS23855 (4889610) 4889610..4891748 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MU415_RS23860 (4892077) 4892077..4892541 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MU415_RS23865 (4892545) 4892545..4892829 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU415_RS23870 (4892819) 4892819..4893061 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MU415_RS23875 (4893139) 4893139..4895049 - 1911 WP_004152270.1 PRD domain-containing protein -
MU415_RS23880 (4895072) 4895072..4896226 - 1155 WP_004178372.1 lactonase family protein -
MU415_RS23885 (4896293) 4896293..4897033 - 741 WP_245146721.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T241465 WP_009486548.1 NZ_CP095132:c4892829-4892545 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T241465 NZ_LT992469:247635-247811 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT241465 WP_002886901.1 NZ_CP095132:c4893061-4892819 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT241465 NZ_LT992469:c247973-247799 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References