Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
| Location | 1818755..1819345 | Replicon | chromosome |
| Accession | NZ_CP095132 | ||
| Organism | Klebsiella pneumoniae strain Iso00267 | ||
Toxin (Protein)
| Gene name | pemK | Uniprot ID | - |
| Locus tag | MU415_RS08855 | Protein ID | WP_023341911.1 |
| Coordinates | 1819013..1819345 (+) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | pemI | Uniprot ID | A0A3S7DDD0 |
| Locus tag | MU415_RS08850 | Protein ID | WP_000288812.1 |
| Coordinates | 1818755..1819012 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MU415_RS08820 (1814397) | 1814397..1814471 | + | 75 | Protein_1728 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| MU415_RS08825 (1814880) | 1814880..1815860 | + | 981 | WP_000019473.1 | IS5-like element ISKpn26 family transposase | - |
| MU415_RS08830 (1815918) | 1815918..1816838 | + | 921 | WP_245146813.1 | hypothetical protein | - |
| MU415_RS08835 (1816917) | 1816917..1817474 | + | 558 | WP_020805022.1 | hypothetical protein | - |
| MU415_RS08840 (1817757) | 1817757..1818217 | + | 461 | Protein_1732 | hypothetical protein | - |
| MU415_RS08845 (1818214) | 1818214..1818420 | + | 207 | WP_020805021.1 | helix-turn-helix transcriptional regulator | - |
| MU415_RS08850 (1818755) | 1818755..1819012 | + | 258 | WP_000288812.1 | antitoxin | Antitoxin |
| MU415_RS08855 (1819013) | 1819013..1819345 | + | 333 | WP_023341911.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| MU415_RS08860 (1819619) | 1819619..1820002 | + | 384 | Protein_1736 | helix-turn-helix domain-containing protein | - |
| MU415_RS08865 (1820005) | 1820005..1820133 | + | 129 | Protein_1737 | phage virion morphogenesis protein | - |
| MU415_RS08870 (1820268) | 1820268..1820519 | + | 252 | WP_001287855.1 | hypothetical protein | - |
| MU415_RS08875 (1820549) | 1820549..1821385 | + | 837 | WP_223175058.1 | hypothetical protein | - |
| MU415_RS08880 (1821405) | 1821405..1821560 | - | 156 | Protein_1740 | IS630 family transposase | - |
| MU415_RS08885 (1822041) | 1822041..1823141 | - | 1101 | WP_000659976.1 | reverse transcriptase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | galF / cpsACP / wzi / wza / gnd / manC / manB / ugd / wzm / wzt / wbbM / glf / wbbN / wbbO | 1688936..1848789 | 159853 | |
| - | flank | IS/Tn | - | - | 1814880..1815860 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11927.87 Da Isoelectric Point: 10.4722
>T241452 WP_023341911.1 NZ_CP095132:1819013-1819345 [Klebsiella pneumoniae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARKGKRLERIPDVVVNEVLARLDAMLS
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARKGKRLERIPDVVVNEVLARLDAMLS
Download Length: 333 bp
>T241452 NZ_LT992468:c378997-378845 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9442.92 Da Isoelectric Point: 4.3566
>AT241452 WP_000288812.1 NZ_CP095132:1818755-1819012 [Klebsiella pneumoniae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL
Download Length: 258 bp
>AT241452 NZ_LT992468:c379621-379022 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAACAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAACAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|