Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4090358..4090953 Replicon chromosome
Accession NZ_CP095125
Organism Escherichia coli strain Iso00270

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag MU416_RS19730 Protein ID WP_000239579.1
Coordinates 4090358..4090708 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag MU416_RS19735 Protein ID WP_001223208.1
Coordinates 4090702..4090953 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU416_RS19710 (4085804) 4085804..4086826 - 1023 WP_001295197.1 ABC transporter permease -
MU416_RS19715 (4086840) 4086840..4088342 - 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
MU416_RS19720 (4088482) 4088482..4089438 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
MU416_RS19725 (4089748) 4089748..4090278 + 531 WP_000055072.1 inorganic diphosphatase -
MU416_RS19730 (4090358) 4090358..4090708 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
MU416_RS19735 (4090702) 4090702..4090953 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
MU416_RS19740 (4091165) 4091165..4091506 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
MU416_RS19745 (4091509) 4091509..4095288 - 3780 WP_245112062.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T241443 WP_000239579.1 NZ_CP095125:c4090708-4090358 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T241443 NZ_LT992466:2194828-2195016 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT241443 WP_001223208.1 NZ_CP095125:c4090953-4090702 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT241443 NZ_LT992466:2194540-2194800 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References