Detailed information of TA system TA241438

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2398213..2398851
• Replicon: chromosome
• Accession: NZ_CP095125
• Organism: Escherichia coli strain Iso00270

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0A6TXU8
• Locus tag: MU416_RS11435
• Protein ID: WP_001447010.1
• Coordinates: 2398675..2398851 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MU416_RS11430
• Protein ID: WP_001270286.1
• Coordinates: 2398213..2398629 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MU416_RS11410 (2393376)	2393376..2394317	-	942	WP_001251304.1	ABC transporter permease	-
MU416_RS11415 (2394318)	2394318..2395331	-	1014	WP_000220395.1	ABC transporter ATP-binding protein	-
MU416_RS11420 (2395349)	2395349..2396494	-	1146	WP_000047428.1	ABC transporter substrate-binding protein	-
MU416_RS11425 (2396728)	2396728..2398134	-	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
MU416_RS11430 (2398213)	2398213..2398629	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
MU416_RS11435 (2398675)	2398675..2398851	-	177	WP_001447010.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
MU416_RS11440 (2399073)	2399073..2399303	+	231	WP_000494244.1	YncJ family protein	-
MU416_RS11445 (2399395)	2399395..2401356	-	1962	WP_001303492.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
MU416_RS11450 (2401429)	2401429..2401965	-	537	WP_000429155.1	DNA-binding transcriptional regulator SutR	-
MU416_RS11455 (2402057)	2402057..2403232	+	1176	WP_001236265.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6779.86 Da
• Isoelectric Point: 11.2298

>T241438 WP_001447010.1 NZ_CP095125:c2398851-2398675 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T241438 NZ_LT992466:940317-940526 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT241438 WP_001270286.1 NZ_CP095125:c2398629-2398213 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT241438 NZ_LT992466:940012-940305 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Toxin

• AlphaFold DB: A0A0A6TXU8