Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 136744..137387 Replicon plasmid pKP1601-1
Accession NZ_CP095122
Organism Klebsiella pneumoniae strain KP1601

Toxin (Protein)


Gene name vagD Uniprot ID A0A3A3ZBE4
Locus tag MUU71_RS26055 Protein ID WP_007374381.1
Coordinates 136971..137387 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID G8LQB1
Locus tag MUU71_RS26050 Protein ID WP_007853351.1
Coordinates 136744..136974 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUU71_RS26025 (MUU71_26025) 132389..132646 - 258 WP_023292103.1 hypothetical protein -
MUU71_RS26030 (MUU71_26030) 133125..133805 + 681 Protein_140 CSS-motif domain-containing protein -
MUU71_RS26035 (MUU71_26035) 133869..134705 + 837 WP_032693954.1 EAL domain-containing protein -
MUU71_RS26040 (MUU71_26040) 135236..135769 - 534 WP_224236739.1 hypothetical protein -
MUU71_RS26045 (MUU71_26045) 135820..136170 - 351 WP_023292071.1 hypothetical protein -
MUU71_RS26050 (MUU71_26050) 136744..136974 + 231 WP_007853351.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MUU71_RS26055 (MUU71_26055) 136971..137387 + 417 WP_007374381.1 type II toxin-antitoxin system VapC family toxin Toxin
MUU71_RS26060 (MUU71_26060) 137460..139022 + 1563 WP_042936981.1 AAA family ATPase -
MUU71_RS26065 (MUU71_26065) 139007..140029 + 1023 WP_007374383.1 hypothetical protein -
MUU71_RS26070 (MUU71_26070) 140238..140795 + 558 WP_065907718.1 OsmC family protein -
MUU71_RS26075 (MUU71_26075) 140979..141548 + 570 WP_065907716.1 TetR/AcrR family transcriptional regulator -
MUU71_RS26080 (MUU71_26080) 141565..141903 + 339 WP_007374386.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..153937 153937


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15105.57 Da        Isoelectric Point: 7.8882

>T241422 WP_007374381.1 NZ_CP095122:136971-137387 [Klebsiella pneumoniae]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYAEMRFGATGPKAAPRHVQLVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

>T241422 NZ_LT992464:691422-691574 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8674.77 Da        Isoelectric Point: 4.4692

>AT241422 WP_007853351.1 NZ_CP095122:136744-136974 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRVNL

Download         Length: 231 bp

>AT241422 NZ_LT992464:690798-691397 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAACAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A3ZBE4

Antitoxin

Source ID Structure
AlphaFold DB A0A3A3Z894

References