Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4626201..4626717 Replicon chromosome
Accession NZ_CP095121
Organism Klebsiella pneumoniae strain KP1601

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag MUU71_RS22380 Protein ID WP_004178374.1
Coordinates 4626201..4626485 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MUU71_RS22385 Protein ID WP_002886901.1
Coordinates 4626475..4626717 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUU71_RS22355 (4621596) 4621596..4621859 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
MUU71_RS22360 (4621989) 4621989..4622162 + 174 WP_032412860.1 hypothetical protein -
MUU71_RS22365 (4622165) 4622165..4622908 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MUU71_RS22370 (4623265) 4623265..4625403 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MUU71_RS22375 (4625733) 4625733..4626197 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MUU71_RS22380 (4626201) 4626201..4626485 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUU71_RS22385 (4626475) 4626475..4626717 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MUU71_RS22390 (4626795) 4626795..4628705 - 1911 WP_004152270.1 PRD domain-containing protein -
MUU71_RS22395 (4628728) 4628728..4629882 - 1155 WP_002886900.1 lactonase family protein -
MUU71_RS22400 (4629949) 4629949..4630689 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T241419 WP_004178374.1 NZ_CP095121:c4626485-4626201 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T241419 NZ_LT992464:468815-469024 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT241419 WP_002886901.1 NZ_CP095121:c4626717-4626475 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT241419 NZ_LT992464:468510-468803 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References