Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3914970..3915589 Replicon chromosome
Accession NZ_CP095121
Organism Klebsiella pneumoniae strain KP1601

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MUU71_RS19040 Protein ID WP_002892050.1
Coordinates 3915371..3915589 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MUU71_RS19035 Protein ID WP_002892066.1
Coordinates 3914970..3915344 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUU71_RS19025 (3910122) 3910122..3911315 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MUU71_RS19030 (3911338) 3911338..3914484 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
MUU71_RS19035 (3914970) 3914970..3915344 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MUU71_RS19040 (3915371) 3915371..3915589 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MUU71_RS19045 (3915752) 3915752..3916318 + 567 WP_002892030.1 maltose O-acetyltransferase -
MUU71_RS19050 (3916290) 3916290..3916430 - 141 WP_004147370.1 hypothetical protein -
MUU71_RS19055 (3916451) 3916451..3916921 + 471 WP_002892026.1 YlaC family protein -
MUU71_RS19060 (3916896) 3916896..3918347 - 1452 WP_064151794.1 PLP-dependent aminotransferase family protein -
MUU71_RS19065 (3918448) 3918448..3919146 + 699 WP_002892021.1 GNAT family protein -
MUU71_RS19070 (3919143) 3919143..3919283 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MUU71_RS19075 (3919283) 3919283..3919546 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T241417 WP_002892050.1 NZ_CP095121:3915371-3915589 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T241417 NZ_LT992464:114211-114318 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT241417 WP_002892066.1 NZ_CP095121:3914970-3915344 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT241417 NZ_LT992464:c114395-114335 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References