Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2659828..2661416 Replicon chromosome
Accession NZ_CP095121
Organism Klebsiella pneumoniae strain KP1601

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MUU71_RS13030 Protein ID WP_064151580.1
Coordinates 2659828..2661150 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MUU71_RS13035 Protein ID WP_004176198.1
Coordinates 2661150..2661416 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUU71_RS13015 (2654884) 2654884..2657385 + 2502 WP_064151582.1 fimbria/pilus outer membrane usher protein -
MUU71_RS13020 (2657373) 2657373..2658377 + 1005 WP_064151581.1 fimbrial protein -
MUU71_RS13025 (2658519) 2658519..2659811 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
MUU71_RS13030 (2659828) 2659828..2661150 - 1323 WP_064151580.1 type II toxin-antitoxin system HipA family toxin Toxin
MUU71_RS13035 (2661150) 2661150..2661416 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
MUU71_RS13040 (2661682) 2661682..2662008 - 327 WP_004176200.1 hydroxyisourate hydrolase -
MUU71_RS13045 (2662005) 2662005..2662505 - 501 WP_064151579.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
MUU71_RS13050 (2662483) 2662483..2663862 - 1380 WP_065799905.1 nucleobase:cation symporter-2 family protein -
MUU71_RS13055 (2664208) 2664208..2665362 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
MUU71_RS13060 (2665343) 2665343..2666266 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T241416 WP_064151580.1 NZ_CP095121:c2661150-2659828 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
AHSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T241416 NZ_LT992463:2823907-2824083 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT241416 WP_004176198.1 NZ_CP095121:c2661416-2661150 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT241416 NZ_LT992463:c2824245-2824071 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References