Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 798555..799212 Replicon chromosome
Accession NZ_CP095121
Organism Klebsiella pneumoniae strain KP1601

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MUU71_RS03965 Protein ID WP_002916310.1
Coordinates 798802..799212 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MUU71_RS03960 Protein ID WP_002916312.1
Coordinates 798555..798821 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUU71_RS03935 (793711) 793711..795144 - 1434 WP_064152027.1 6-phospho-beta-glucosidase -
MUU71_RS03940 (795263) 795263..795991 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MUU71_RS03945 (796041) 796041..796352 + 312 WP_064152028.1 N(4)-acetylcytidine aminohydrolase -
MUU71_RS03950 (796516) 796516..797175 + 660 WP_002916317.1 hemolysin III family protein -
MUU71_RS03955 (797326) 797326..798309 - 984 WP_064152029.1 tRNA-modifying protein YgfZ -
MUU71_RS03960 (798555) 798555..798821 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MUU71_RS03965 (798802) 798802..799212 + 411 WP_002916310.1 protein YgfX Toxin
MUU71_RS03970 (799219) 799219..799740 - 522 WP_004144730.1 flavodoxin FldB -
MUU71_RS03975 (799841) 799841..800737 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MUU71_RS03980 (800760) 800760..801473 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MUU71_RS03985 (801479) 801479..803212 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T241407 WP_002916310.1 NZ_CP095121:798802-799212 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T241407 NZ_LT992462:c2256539-2256432 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT241407 WP_002916312.1 NZ_CP095121:798555-798821 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT241407 NZ_LT992462:2256355-2256415 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References