Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2218148..2218662 Replicon chromosome
Accession NZ_CP095119
Organism Staphylococcus aureus strain IVB6154

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MUA68_RS11340 Protein ID WP_262520410.1
Coordinates 2218148..2218357 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA68_RS11345 Protein ID WP_000138934.1
Coordinates 2218369..2218662 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA68_RS11320 (2213656) 2213656..2215014 - 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUA68_RS11325 (2215029) 2215029..2216099 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MUA68_RS11330 (2216417) 2216417..2217619 + 1203 WP_262520409.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA68_RS11335 (2217883) 2217883..2218020 - 138 WP_000828354.1 Lmo0850 family protein -
MUA68_RS11340 (2218148) 2218148..2218357 - 210 WP_262520410.1 heavy metal-associated domain-containing protein Toxin
MUA68_RS11345 (2218369) 2218369..2218662 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA68_RS11350 (2218828) 2218828..2220312 + 1485 WP_262520411.1 cardiolipin synthase -
MUA68_RS11355 (2220340) 2220340..2220987 + 648 Protein_2202 HD domain-containing protein -
MUA68_RS11360 (2221560) 2221560..2222432 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA68_RS11365 (2222518) 2222518..2223159 - 642 WP_262520413.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7873.80 Da        Isoelectric Point: 4.1008

>T241399 WP_262520410.1 NZ_CP095119:c2218357-2218148 [Staphylococcus aureus]
MIHQNTIYTSGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKILF

Download         Length: 210 bp

>T241399 NZ_LT992462:c782416-782165 [Staphylococcus aureus]
ATGAATAATCGCGAAAAAATCGAACAGTCCGTTATTAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT241399 WP_000138934.1 NZ_CP095119:c2218662-2218369 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT241399 NZ_LT992462:c782175-782002 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References