Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1980113..1980889 Replicon chromosome
Accession NZ_CP095119
Organism Staphylococcus aureus strain IVB6154

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUA68_RS09920 Protein ID WP_000031108.1
Coordinates 1980113..1980265 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag MUA68_RS09925 Protein ID WP_001251224.1
Coordinates 1980290..1980889 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA68_RS09905 (1976149) 1976149..1976970 + 822 WP_000669380.1 RluA family pseudouridine synthase -
MUA68_RS09910 (1977434) 1977434..1978819 - 1386 WP_262520252.1 class II fumarate hydratase -
MUA68_RS09915 (1979015) 1979015..1979410 - 396 WP_262520253.1 hypothetical protein -
MUA68_RS09920 (1980113) 1980113..1980265 - 153 WP_000031108.1 SAS053 family protein Toxin
MUA68_RS09925 (1980290) 1980290..1980889 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
MUA68_RS09930 (1981048) 1981048..1981518 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA68_RS09935 (1981523) 1981523..1982650 - 1128 WP_262520255.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA68_RS09940 (1982801) 1982801..1983523 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MUA68_RS09945 (1983516) 1983516..1984973 - 1458 WP_262520256.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T241394 WP_000031108.1 NZ_CP095119:c1980265-1980113 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T241394 NZ_LT992461:2061285-2061392 [Staphylococcus aureus]
GTGATATCTATTGCAAATGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT241394 WP_001251224.1 NZ_CP095119:c1980889-1980290 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT241394 NZ_LT992461:c2061501-2061387 [Staphylococcus aureus]
TAAAAAGACGACATGCAGTAACATGTCGCCTAATGAGCCCGTTAAAAAGACGGTGACTAAATGAGATTTGCTTTAACCAT
CATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References