Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 889570..890047 Replicon chromosome
Accession NZ_CP095119
Organism Staphylococcus aureus strain IVB6154

Toxin (Protein)


Gene name TsaT Uniprot ID -
Locus tag MUA68_RS04455 Protein ID WP_262521583.1
Coordinates 889570..889758 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MUA68_RS04460 Protein ID WP_001059690.1
Coordinates 889787..890047 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA68_RS04425 (885602) 885602..886084 + 483 WP_262521577.1 hypothetical protein -
MUA68_RS04430 (886425) 886425..887108 + 684 WP_262521579.1 thermonuclease family protein -
MUA68_RS04435 (887465) 887465..887665 + 201 WP_001059082.1 cold-shock protein -
MUA68_RS04440 (888162) 888162..888380 - 219 WP_262521581.1 hypothetical protein -
MUA68_RS04445 (888441) 888441..888725 - 285 WP_001004401.1 hypothetical protein -
MUA68_RS04450 (888813) 888813..889382 - 570 WP_262521582.1 lipoprotein N-acylation protein LnsA -
MUA68_RS04455 (889570) 889570..889758 - 189 WP_262521583.1 hypothetical protein Toxin
MUA68_RS04460 (889787) 889787..890047 - 261 WP_001059690.1 hypothetical protein Antitoxin
MUA68_RS04465 (890388) 890388..890591 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MUA68_RS04470 (890588) 890588..890824 - 237 WP_000368687.1 hypothetical protein -
MUA68_RS04475 (891049) 891049..891630 + 582 WP_262521584.1 histidine phosphatase family protein -
MUA68_RS04480 (891703) 891703..892320 - 618 WP_262521585.1 LysE/ArgO family amino acid transporter -
MUA68_RS04485 (892476) 892476..892970 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
MUA68_RS04490 (893369) 893369..893791 - 423 WP_262521586.1 organic hydroperoxide resistance protein -
MUA68_RS04495 (893939) 893939..894655 + 717 WP_262521587.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7158.81 Da        Isoelectric Point: 9.9971

>T241387 WP_262521583.1 NZ_CP095119:c889758-889570 [Staphylococcus aureus]
MSLHFAILFWLSLIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T241387 NZ_LT992461:c213520-213344 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT241387 WP_001059690.1 NZ_CP095119:c890047-889787 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT241387 NZ_LT992461:213221-213276 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References