Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2202764..2203278 Replicon chromosome
Accession NZ_CP095116
Organism Staphylococcus aureus strain IVB6156

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MUA78_RS11040 Protein ID WP_000603099.1
Coordinates 2202764..2202973 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MUA78_RS11045 Protein ID WP_000138933.1
Coordinates 2202985..2203278 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA78_RS11020 (2198272) 2198272..2199630 - 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUA78_RS11025 (2199645) 2199645..2200715 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MUA78_RS11030 (2201033) 2201033..2202235 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA78_RS11035 (2202499) 2202499..2202636 - 138 WP_000828354.1 Lmo0850 family protein -
MUA78_RS11040 (2202764) 2202764..2202973 - 210 WP_000603099.1 heavy metal-associated domain-containing protein Toxin
MUA78_RS11045 (2202985) 2202985..2203278 - 294 WP_000138933.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA78_RS11050 (2203444) 2203444..2204928 + 1485 WP_000571551.1 cardiolipin synthase -
MUA78_RS11055 (2204956) 2204956..2205618 + 663 WP_001187618.1 HD domain-containing protein -
MUA78_RS11060 (2206175) 2206175..2207047 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA78_RS11065 (2207133) 2207133..2207774 - 642 WP_000483158.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7819.79 Da        Isoelectric Point: 3.9389

>T241375 WP_000603099.1 NZ_CP095116:c2202973-2202764 [Staphylococcus aureus]
MILQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T241375 NZ_LT992458:2558465-2558653 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.81 Da        Isoelectric Point: 6.7122

>AT241375 WP_000138933.1 NZ_CP095116:c2203278-2202985 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNKGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT241375 NZ_LT992458:2558177-2558437 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References