Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2183021..2183550 Replicon chromosome
Accession NZ_CP095116
Organism Staphylococcus aureus strain IVB6156

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA78_RS10950 Protein ID WP_000621175.1
Coordinates 2183021..2183383 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag MUA78_RS10955 Protein ID WP_000948331.1
Coordinates 2183380..2183550 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA78_RS10930 (2179999) 2179999..2180769 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
MUA78_RS10935 (2180744) 2180744..2181223 - 480 WP_001190825.1 anti-sigma B factor RsbW -
MUA78_RS10940 (2181225) 2181225..2181551 - 327 WP_001052491.1 anti-sigma factor antagonist -
MUA78_RS10945 (2181670) 2181670..2182671 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
MUA78_RS10950 (2183021) 2183021..2183383 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA78_RS10955 (2183380) 2183380..2183550 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA78_RS10960 (2183635) 2183635..2184783 - 1149 WP_262515172.1 alanine racemase -
MUA78_RS10965 (2184849) 2184849..2185208 - 360 WP_000581198.1 holo-ACP synthase -
MUA78_RS10970 (2185212) 2185212..2185703 - 492 WP_262515173.1 PH domain-containing protein -
MUA78_RS10975 (2185690) 2185690..2187273 - 1584 WP_001294641.1 PH domain-containing protein -
MUA78_RS10980 (2187266) 2187266..2187745 - 480 WP_001287083.1 hypothetical protein -
MUA78_RS10985 (2187954) 2187954..2188514 - 561 WP_262515174.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T241374 WP_000621175.1 NZ_CP095116:c2183383-2183021 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T241374 NZ_LT992458:c2402484-2402377 [Staphylococcus aureus]
GTGATATCTATTGCAAATGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT241374 WP_000948331.1 NZ_CP095116:c2183550-2183380 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT241374 NZ_LT992458:2402287-2402324 [Staphylococcus aureus]
AACATGTCGCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References