Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2065546..2066023 Replicon chromosome
Accession NZ_CP095116
Organism Staphylococcus aureus strain IVB6156

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MUA78_RS10405 Protein ID WP_000052076.1
Coordinates 2065835..2066023 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MUA78_RS10400 Protein ID WP_001059690.1
Coordinates 2065546..2065806 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA78_RS10365 (2060938) 2060938..2061654 - 717 WP_262515154.1 type I 3-dehydroquinate dehydratase -
MUA78_RS10370 (2061802) 2061802..2062224 + 423 WP_000974454.1 organic hydroperoxide resistance protein -
MUA78_RS10375 (2062623) 2062623..2063117 + 495 WP_262515155.1 GNAT family N-acetyltransferase -
MUA78_RS10380 (2063273) 2063273..2063890 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
MUA78_RS10385 (2063963) 2063963..2064544 - 582 WP_001140691.1 histidine phosphatase family protein -
MUA78_RS10390 (2064769) 2064769..2065005 + 237 WP_000368687.1 hypothetical protein -
MUA78_RS10395 (2065002) 2065002..2065205 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MUA78_RS10400 (2065546) 2065546..2065806 + 261 WP_001059690.1 hypothetical protein Antitoxin
MUA78_RS10405 (2065835) 2065835..2066023 + 189 WP_000052076.1 hypothetical protein Toxin
MUA78_RS10410 (2066211) 2066211..2066780 + 570 WP_001106650.1 lipoprotein N-acylation protein LnsA -
MUA78_RS10415 (2066868) 2066868..2067152 + 285 WP_001004401.1 hypothetical protein -
MUA78_RS10420 (2067214) 2067214..2067432 + 219 WP_000005880.1 hypothetical protein -
MUA78_RS10425 (2067930) 2067930..2068130 - 201 WP_001059082.1 cold-shock protein -
MUA78_RS10430 (2068487) 2068487..2069173 - 687 WP_001804081.1 thermonuclease family protein -
MUA78_RS10435 (2069514) 2069514..2069983 - 470 Protein_2023 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / vWbp / vWbp 1991437..2079105 87668


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T241373 WP_000052076.1 NZ_CP095116:2065835-2066023 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T241373 NZ_LT992458:1515105-1515257 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT241373 WP_001059690.1 NZ_CP095116:2065546-2065806 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT241373 NZ_LT992458:1514481-1515080 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAACAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References