Detailed information of TA system TA241372

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2048710..2049248
• Replicon: chromosome
• Accession: NZ_CP095116
• Organism: Staphylococcus aureus strain IVB6156

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA78_RS10270
• Protein ID: WP_045178618.1
• Coordinates: 2048710..2049036 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA78_RS10275
• Protein ID: WP_262515150.1
• Coordinates: 2049039..2049248 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA78_RS10240 (2044034)	2044034..2044375	-	342	WP_001190600.1	hypothetical protein	-
MUA78_RS10245 (2044723)	2044723..2045364	-	642	WP_262515148.1	pathogenicity island protein	-
MUA78_RS10250 (2045361)	2045361..2045645	-	285	WP_045178623.1	hypothetical protein	-
MUA78_RS10255 (2045647)	2045647..2046009	-	363	WP_045178622.1	hypothetical protein	-
MUA78_RS10260 (2046302)	2046302..2047759	-	1458	WP_045178620.1	virulence-associated E family protein	-
MUA78_RS10265 (2047776)	2047776..2048645	-	870	WP_262515149.1	primase alpha helix C-terminal domain-containing protein	-
MUA78_RS10270 (2048710)	2048710..2049036	-	327	WP_045178618.1	DUF1474 family protein	Toxin
MUA78_RS10275 (2049039)	2049039..2049248	-	210	WP_262515150.1	pathogenicity island protein	Antitoxin
MUA78_RS10280 (2049241)	2049241..2049387	-	147	WP_250406348.1	pathogenicity island protein	-
MUA78_RS10285 (2049399)	2049399..2049671	-	273	WP_250425965.1	helix-turn-helix domain-containing protein	-
MUA78_RS10290 (2049687)	2049687..2049941	-	255	WP_250425964.1	helix-turn-helix transcriptional regulator	-
MUA78_RS10295 (2050132)	2050132..2050770	+	639	WP_250406350.1	XRE family transcriptional regulator	-
MUA78_RS10300 (2050967)	2050967..2051134	+	168	WP_031806878.1	hypothetical protein	-
MUA78_RS10305 (2051274)	2051274..2051954	+	681	WP_250406351.1	type II toxin-antitoxin system PemK/MazF family toxin	-
MUA78_RS10310 (2052165)	2052165..2053385	+	1221	WP_262515151.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / vWbp / vWbp	1991437..2079105	87668

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13165.42 Da
• Isoelectric Point: 4.5527

>T241372 WP_045178618.1 NZ_CP095116:c2049036-2048710 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T241372 NZ_LT992458:1405243-1405419 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8253.40 Da
• Isoelectric Point: 4.6311

>AT241372 WP_262515150.1 NZ_CP095116:c2049248-2049039 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLKLSVMNNLECYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT241372 NZ_LT992458:c1405581-1405407 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG