Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2048710..2049248 Replicon chromosome
Accession NZ_CP095116
Organism Staphylococcus aureus strain IVB6156

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag MUA78_RS10270 Protein ID WP_045178618.1
Coordinates 2048710..2049036 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag MUA78_RS10275 Protein ID WP_262515150.1
Coordinates 2049039..2049248 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA78_RS10240 (2044034) 2044034..2044375 - 342 WP_001190600.1 hypothetical protein -
MUA78_RS10245 (2044723) 2044723..2045364 - 642 WP_262515148.1 pathogenicity island protein -
MUA78_RS10250 (2045361) 2045361..2045645 - 285 WP_045178623.1 hypothetical protein -
MUA78_RS10255 (2045647) 2045647..2046009 - 363 WP_045178622.1 hypothetical protein -
MUA78_RS10260 (2046302) 2046302..2047759 - 1458 WP_045178620.1 virulence-associated E family protein -
MUA78_RS10265 (2047776) 2047776..2048645 - 870 WP_262515149.1 primase alpha helix C-terminal domain-containing protein -
MUA78_RS10270 (2048710) 2048710..2049036 - 327 WP_045178618.1 DUF1474 family protein Toxin
MUA78_RS10275 (2049039) 2049039..2049248 - 210 WP_262515150.1 pathogenicity island protein Antitoxin
MUA78_RS10280 (2049241) 2049241..2049387 - 147 WP_250406348.1 pathogenicity island protein -
MUA78_RS10285 (2049399) 2049399..2049671 - 273 WP_250425965.1 helix-turn-helix domain-containing protein -
MUA78_RS10290 (2049687) 2049687..2049941 - 255 WP_250425964.1 helix-turn-helix transcriptional regulator -
MUA78_RS10295 (2050132) 2050132..2050770 + 639 WP_250406350.1 XRE family transcriptional regulator -
MUA78_RS10300 (2050967) 2050967..2051134 + 168 WP_031806878.1 hypothetical protein -
MUA78_RS10305 (2051274) 2051274..2051954 + 681 WP_250406351.1 type II toxin-antitoxin system PemK/MazF family toxin -
MUA78_RS10310 (2052165) 2052165..2053385 + 1221 WP_262515151.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / vWbp / vWbp 1991437..2079105 87668


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 13165.42 Da        Isoelectric Point: 4.5527

>T241372 WP_045178618.1 NZ_CP095116:c2049036-2048710 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T241372 NZ_LT992458:1405243-1405419 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8253.40 Da        Isoelectric Point: 4.6311

>AT241372 WP_262515150.1 NZ_CP095116:c2049248-2049039 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLKLSVMNNLECYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT241372 NZ_LT992458:c1405581-1405407 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References