Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 967681..968478 Replicon chromosome
Accession NZ_CP095116
Organism Staphylococcus aureus strain IVB6156

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag MUA78_RS04875 Protein ID WP_000525004.1
Coordinates 967681..968142 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag MUA78_RS04880 Protein ID WP_001260487.1
Coordinates 968155..968478 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA78_RS04820 (963604) 963604..964158 + 555 WP_000132893.1 alpha/beta hydrolase -
MUA78_RS04865 (965445) 965445..966494 - 1050 WP_262515394.1 site-specific integrase -
MUA78_RS04870 (966742) 966742..967662 - 921 WP_262515395.1 DUF5067 domain-containing protein -
MUA78_RS04875 (967681) 967681..968142 - 462 WP_000525004.1 hypothetical protein Toxin
MUA78_RS04880 (968155) 968155..968478 - 324 WP_001260487.1 helix-turn-helix transcriptional regulator Antitoxin
MUA78_RS04885 (968644) 968644..968892 + 249 WP_262515396.1 helix-turn-helix transcriptional regulator -
MUA78_RS04890 (968908) 968908..969699 + 792 WP_262515397.1 phage antirepressor KilAC domain-containing protein -
MUA78_RS04895 (969700) 969700..969924 + 225 WP_262515398.1 hypothetical protein -
MUA78_RS04900 (969964) 969964..970167 + 204 WP_000394020.1 hypothetical protein -
MUA78_RS04905 (970164) 970164..970298 - 135 WP_262515399.1 hypothetical protein -
MUA78_RS04910 (970355) 970355..971080 + 726 WP_262515400.1 BRO family protein -
MUA78_RS04915 (971105) 971105..971314 + 210 WP_262515401.1 hypothetical protein -
MUA78_RS04920 (971328) 971328..971489 + 162 WP_001285962.1 DUF1270 domain-containing protein -
MUA78_RS04925 (971583) 971583..971843 + 261 WP_031862972.1 DUF1108 family protein -
MUA78_RS04930 (971853) 971853..972074 + 222 WP_000815401.1 DUF2483 family protein -
MUA78_RS04935 (972067) 972067..972690 + 624 WP_000139720.1 DUF1071 domain-containing protein -
MUA78_RS04940 (972690) 972690..973115 + 426 WP_262515402.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hlgA / lukD 963604..1025000 61396


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T241365 WP_000525004.1 NZ_CP095116:c968142-967681 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T241365 NZ_LT992456:c2569877-2569416 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT241365 WP_001260487.1 NZ_CP095116:c968478-968155 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT241365 NZ_LT992456:c2570204-2569890 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References