Detailed information of TA system TA241363

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 424177..424709
• Replicon: chromosome
• Accession: NZ_CP095116
• Organism: Staphylococcus aureus strain IVB6156

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA78_RS01955
• Protein ID: WP_262515319.1
• Coordinates: 424389..424709 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA78_RS01950
• Protein ID: WP_262515318.1
• Coordinates: 424177..424386 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA78_RS01915 (419693)	419693..419935	+	243	WP_000897044.1	30S ribosomal protein S18	-
MUA78_RS01920 (420150)	420150..421139	-	990	WP_250425947.1	Abi family protein	-
MUA78_RS01925 (421145)	421145..422359	-	1215	WP_262515315.1	site-specific integrase	-
MUA78_RS01930 (422657)	422657..423391	-	735	WP_262515316.1	helix-turn-helix transcriptional regulator	-
MUA78_RS01935 (423541)	423541..423753	+	213	WP_001063623.1	helix-turn-helix transcriptional regulator	-
MUA78_RS01940 (423754)	423754..424026	+	273	WP_001138303.1	helix-turn-helix domain-containing protein	-
MUA78_RS01945 (424038)	424038..424184	+	147	WP_262515317.1	pathogenicity island protein	-
MUA78_RS01950 (424177)	424177..424386	+	210	WP_262515318.1	pathogenicity island protein	Antitoxin
MUA78_RS01955 (424389)	424389..424709	+	321	WP_262515319.1	DUF1474 family protein	Toxin
MUA78_RS01960 (424780)	424780..427032	+	2253	WP_262515320.1	phage/plasmid primase, P4 family	-
MUA78_RS01965 (427303)	427303..427647	+	345	WP_000567971.1	hypothetical protein	-
MUA78_RS01970 (427649)	427649..428290	+	642	WP_262515321.1	pathogenicity island protein	-
MUA78_RS01975 (428998)	428998..429342	+	345	WP_001288441.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	415079..437928	22849

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12866.23 Da
• Isoelectric Point: 5.4808

>T241363 WP_262515319.1 NZ_CP095116:424389-424709 [Staphylococcus aureus]
MNWEINDLFNDLKVLKDRFEDLKDNHGWHFDNFYPHEPNHVLNKTEAIKEGFSYHERRIHNNQMFDLFHLYIEQFDNIIQ
KFHEIEKASSENFGEVSDDAKNVKKA

Nucleotide

• Length: 321 bp

>T241363 NZ_LT992456:2099676-2099852 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8224.25 Da
• Isoelectric Point: 4.3718

>AT241363 WP_262515318.1 NZ_CP095116:424177-424386 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT241363 NZ_LT992456:c2100014-2099840 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG