Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 424177..424709 Replicon chromosome
Accession NZ_CP095116
Organism Staphylococcus aureus strain IVB6156

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag MUA78_RS01955 Protein ID WP_262515319.1
Coordinates 424389..424709 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag MUA78_RS01950 Protein ID WP_262515318.1
Coordinates 424177..424386 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA78_RS01915 (419693) 419693..419935 + 243 WP_000897044.1 30S ribosomal protein S18 -
MUA78_RS01920 (420150) 420150..421139 - 990 WP_250425947.1 Abi family protein -
MUA78_RS01925 (421145) 421145..422359 - 1215 WP_262515315.1 site-specific integrase -
MUA78_RS01930 (422657) 422657..423391 - 735 WP_262515316.1 helix-turn-helix transcriptional regulator -
MUA78_RS01935 (423541) 423541..423753 + 213 WP_001063623.1 helix-turn-helix transcriptional regulator -
MUA78_RS01940 (423754) 423754..424026 + 273 WP_001138303.1 helix-turn-helix domain-containing protein -
MUA78_RS01945 (424038) 424038..424184 + 147 WP_262515317.1 pathogenicity island protein -
MUA78_RS01950 (424177) 424177..424386 + 210 WP_262515318.1 pathogenicity island protein Antitoxin
MUA78_RS01955 (424389) 424389..424709 + 321 WP_262515319.1 DUF1474 family protein Toxin
MUA78_RS01960 (424780) 424780..427032 + 2253 WP_262515320.1 phage/plasmid primase, P4 family -
MUA78_RS01965 (427303) 427303..427647 + 345 WP_000567971.1 hypothetical protein -
MUA78_RS01970 (427649) 427649..428290 + 642 WP_262515321.1 pathogenicity island protein -
MUA78_RS01975 (428998) 428998..429342 + 345 WP_001288441.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 415079..437928 22849


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12866.23 Da        Isoelectric Point: 5.4808

>T241363 WP_262515319.1 NZ_CP095116:424389-424709 [Staphylococcus aureus]
MNWEINDLFNDLKVLKDRFEDLKDNHGWHFDNFYPHEPNHVLNKTEAIKEGFSYHERRIHNNQMFDLFHLYIEQFDNIIQ
KFHEIEKASSENFGEVSDDAKNVKKA

Download         Length: 321 bp

>T241363 NZ_LT992456:2099676-2099852 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8224.25 Da        Isoelectric Point: 4.3718

>AT241363 WP_262515318.1 NZ_CP095116:424177-424386 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT241363 NZ_LT992456:c2100014-2099840 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References