Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2182726..2183240 Replicon chromosome
Accession NZ_CP095112
Organism Staphylococcus aureus strain IVB6157

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag MUA55_RS10825 Protein ID WP_000581791.1
Coordinates 2182726..2182935 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA55_RS10830 Protein ID WP_000138934.1
Coordinates 2182947..2183240 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA55_RS10800 (MUA55_10805) 2178083..2179285 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA55_RS10805 (MUA55_10810) 2179446..2179655 - 210 Protein_2088 transposase -
MUA55_RS10810 (MUA55_10815) 2179717..2181363 - 1647 WP_000277709.1 IS1182-like element ISSau3 family transposase -
MUA55_RS10815 (MUA55_10820) 2181640..2182049 - 410 Protein_2090 transposase -
MUA55_RS10820 (MUA55_10825) 2182461..2182598 - 138 WP_000828354.1 Lmo0850 family protein -
MUA55_RS10825 (MUA55_10830) 2182726..2182935 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
MUA55_RS10830 (MUA55_10835) 2182947..2183240 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA55_RS10835 (MUA55_10840) 2183406..2184890 + 1485 WP_000571560.1 cardiolipin synthase -
MUA55_RS10840 (MUA55_10845) 2184918..2185565 + 648 WP_001187612.1 HD domain-containing protein -
MUA55_RS10845 (MUA55_10850) 2186278..2187150 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA55_RS10850 (MUA55_10855) 2187236..2187877 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T241354 WP_000581791.1 NZ_CP095112:c2182935-2182726 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T241354 NZ_LT992436:c1446746-1446639 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT241354 WP_000138934.1 NZ_CP095112:c2183240-2182947 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT241354 NZ_LT992436:1446562-1446622 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References