Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2160070..2160599 Replicon chromosome
Accession NZ_CP095112
Organism Staphylococcus aureus strain IVB6157

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag MUA55_RS10720 Protein ID WP_000621176.1
Coordinates 2160070..2160432 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag MUA55_RS10725 Protein ID WP_000948331.1
Coordinates 2160429..2160599 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA55_RS10700 (MUA55_10705) 2157048..2157818 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
MUA55_RS10705 (MUA55_10710) 2157793..2158272 - 480 WP_001190825.1 anti-sigma B factor RsbW -
MUA55_RS10710 (MUA55_10715) 2158274..2158600 - 327 WP_001052491.1 anti-sigma factor antagonist -
MUA55_RS10715 (MUA55_10720) 2158719..2159720 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
MUA55_RS10720 (MUA55_10725) 2160070..2160432 - 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA55_RS10725 (MUA55_10730) 2160429..2160599 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA55_RS10730 (MUA55_10735) 2160684..2161832 - 1149 WP_001281140.1 alanine racemase -
MUA55_RS10735 (MUA55_10740) 2161898..2162257 - 360 WP_000581197.1 holo-ACP synthase -
MUA55_RS10740 (MUA55_10745) 2162261..2162752 - 492 WP_001286801.1 PH domain-containing protein -
MUA55_RS10745 (MUA55_10750) 2162745..2164322 - 1578 WP_001294646.1 PH domain-containing protein -
MUA55_RS10750 (MUA55_10755) 2164315..2164794 - 480 WP_001287082.1 hypothetical protein -
MUA55_RS10755 (MUA55_10760) 2165003..2165563 - 561 WP_262518315.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T241353 WP_000621176.1 NZ_CP095112:c2160432-2160070 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T241353 NZ_LT992436:c1103810-1103601 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAAAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT241353 WP_000948331.1 NZ_CP095112:c2160599-2160429 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT241353 NZ_LT992436:c1104115-1103822 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAAAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CATTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References