Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2004071..2004847 Replicon chromosome
Accession NZ_CP095112
Organism Staphylococcus aureus strain IVB6157

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUA55_RS09835 Protein ID WP_000031108.1
Coordinates 2004071..2004223 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag MUA55_RS09840 Protein ID WP_001251219.1
Coordinates 2004248..2004847 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA55_RS09820 (MUA55_09825) 2000216..2001037 + 822 WP_000669380.1 RluA family pseudouridine synthase -
MUA55_RS09825 (MUA55_09830) 2001493..2002878 - 1386 WP_262518294.1 class II fumarate hydratase -
MUA55_RS09830 (MUA55_09835) 2003074..2003469 - 396 WP_045179323.1 hypothetical protein -
MUA55_RS09835 (MUA55_09840) 2004071..2004223 - 153 WP_000031108.1 SAS053 family protein Toxin
MUA55_RS09840 (MUA55_09845) 2004248..2004847 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
MUA55_RS09845 (MUA55_09850) 2005006..2005476 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA55_RS09850 (MUA55_09855) 2005481..2006608 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA55_RS09855 (MUA55_09860) 2006759..2007481 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MUA55_RS09860 (MUA55_09865) 2007474..2008931 - 1458 WP_000649898.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T241352 WP_000031108.1 NZ_CP095112:c2004223-2004071 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T241352 NZ_LT992436:c1084220-1083858 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT241352 WP_001251219.1 NZ_CP095112:c2004847-2004248 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT241352 NZ_LT992436:c1084387-1084217 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References