Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 903500..903977 Replicon chromosome
Accession NZ_CP095112
Organism Staphylococcus aureus strain IVB6157

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MUA55_RS04395 Protein ID WP_000052076.1
Coordinates 903500..903688 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MUA55_RS04400 Protein ID WP_001059690.1
Coordinates 903717..903977 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA55_RS04365 (MUA55_04370) 899453..900010 + 558 WP_045178710.1 hypothetical protein -
MUA55_RS04370 (MUA55_04375) 900351..901037 + 687 WP_001574556.1 thermonuclease family protein -
MUA55_RS04375 (MUA55_04380) 901394..901594 + 201 WP_001059082.1 cold-shock protein -
MUA55_RS04380 (MUA55_04385) 902091..902309 - 219 WP_000005879.1 hypothetical protein -
MUA55_RS04385 (MUA55_04390) 902371..902655 - 285 WP_001004401.1 hypothetical protein -
MUA55_RS04390 (MUA55_04395) 902743..903312 - 570 WP_001106663.1 lipoprotein N-acylation protein LnsA -
MUA55_RS04395 (MUA55_04400) 903500..903688 - 189 WP_000052076.1 hypothetical protein Toxin
MUA55_RS04400 (MUA55_04405) 903717..903977 - 261 WP_001059690.1 hypothetical protein Antitoxin
MUA55_RS04405 (MUA55_04410) 904318..904521 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MUA55_RS04410 (MUA55_04415) 904518..904754 - 237 WP_000368687.1 hypothetical protein -
MUA55_RS04415 (MUA55_04420) 904979..905560 + 582 WP_001140696.1 histidine phosphatase family protein -
MUA55_RS04420 (MUA55_04425) 905633..906250 - 618 WP_000255548.1 LysE/ArgO family amino acid transporter -
MUA55_RS04425 (MUA55_04430) 906406..906900 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
MUA55_RS04430 (MUA55_04435) 907299..907721 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
MUA55_RS04435 (MUA55_04440) 907869..908585 + 717 WP_000150025.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T241346 WP_000052076.1 NZ_CP095112:c903688-903500 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T241346 NZ_LT992435:c1103810-1103601 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAAAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT241346 WP_001059690.1 NZ_CP095112:c903977-903717 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT241346 NZ_LT992435:c1104115-1103822 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAAAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CATTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References