Detailed information of TA system TA241341

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 2201383..2201897
• Replicon: chromosome
• Accession: NZ_CP095109
• Organism: Staphylococcus aureus strain IVB6171

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: MUA24_RS11245
• Protein ID: WP_262520410.1
• Coordinates: 2201383..2201592 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A0D1GBN9
• Locus tag: MUA24_RS11250
• Protein ID: WP_000138934.1
• Coordinates: 2201604..2201897 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA24_RS11225 (MUA24_11180)	2196891..2198249	-	1359	WP_262532735.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
MUA24_RS11230 (MUA24_11185)	2198264..2199334	-	1071	WP_000159631.1	D-alanine--D-alanine ligase	-
MUA24_RS11235 (MUA24_11190)	2199652..2200854	+	1203	WP_262532736.1	FtsW/RodA/SpoVE family cell cycle protein	-
MUA24_RS11240 (MUA24_11195)	2201118..2201255	-	138	WP_000828354.1	Lmo0850 family protein	-
MUA24_RS11245 (MUA24_11200)	2201383..2201592	-	210	WP_262520410.1	heavy metal-associated domain-containing protein	Toxin
MUA24_RS11250 (MUA24_11205)	2201604..2201897	-	294	WP_000138934.1	copper-sensing transcriptional repressor CsoR	Antitoxin
MUA24_RS11255 (MUA24_11210)	2202063..2203547	+	1485	WP_262520411.1	cardiolipin synthase	-
MUA24_RS11260 (MUA24_11215)	2203575..2204222	+	648	WP_262532737.1	HD domain-containing protein	-
MUA24_RS11265 (MUA24_11220)	2205095..2205967	-	873	WP_000725802.1	membrane protein insertase YidC	-
MUA24_RS11270 (MUA24_11225)	2206053..2206694	-	642	WP_262532738.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7873.80 Da
• Isoelectric Point: 4.1008

>T241341 WP_262520410.1 NZ_CP095109:c2201592-2201383 [Staphylococcus aureus]
MIHQNTIYTSGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKILF

Nucleotide

• Length: 210 bp

>T241341 NZ_LT992434:2560771-2561088 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGTATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11185.77 Da
• Isoelectric Point: 6.2243

>AT241341 WP_000138934.1 NZ_CP095109:c2201897-2201604 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT241341 NZ_LT992434:2560559-2560768 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATAGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0D1GBN9