Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2179763..2180292 Replicon chromosome
Accession NZ_CP095109
Organism Staphylococcus aureus strain IVB6171

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA24_RS11145 Protein ID WP_000621175.1
Coordinates 2179763..2180125 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag MUA24_RS11150 Protein ID WP_000948331.1
Coordinates 2180122..2180292 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA24_RS11125 (MUA24_11080) 2176742..2177512 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
MUA24_RS11130 (MUA24_11085) 2177487..2177966 - 480 WP_001190825.1 anti-sigma B factor RsbW -
MUA24_RS11135 (MUA24_11090) 2177968..2178294 - 327 WP_001052491.1 anti-sigma factor antagonist -
MUA24_RS11140 (MUA24_11095) 2178413..2179414 - 1002 WP_262532726.1 PP2C family protein-serine/threonine phosphatase -
MUA24_RS11145 (MUA24_11100) 2179763..2180125 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA24_RS11150 (MUA24_11105) 2180122..2180292 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA24_RS11155 (MUA24_11110) 2180377..2181525 - 1149 WP_262532727.1 alanine racemase -
MUA24_RS11160 (MUA24_11115) 2181591..2181950 - 360 WP_262532728.1 holo-ACP synthase -
MUA24_RS11165 (MUA24_11120) 2181954..2182116 - 163 Protein_2165 PH domain-containing protein -
MUA24_RS11170 (MUA24_11125) 2182195..2183481 - 1287 WP_262534624.1 group II intron reverse transcriptase/maturase -
MUA24_RS11175 (MUA24_11130) 2183989..2184315 - 327 Protein_2167 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T241340 WP_000621175.1 NZ_CP095109:c2180125-2179763 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T241340 NZ_LT992434:c1446740-1446633 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT241340 WP_000948331.1 NZ_CP095109:c2180292-2180122 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT241340 NZ_LT992434:1446556-1446616 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References