Detailed information of TA system TA241332

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1063377..1063854
• Replicon: chromosome
• Accession: NZ_CP095109
• Organism: Staphylococcus aureus strain IVB6171

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: -
• Locus tag: MUA24_RS05560
• Protein ID: WP_262521583.1
• Coordinates: 1063377..1063565 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA24_RS05565
• Protein ID: WP_001059690.1
• Coordinates: 1063594..1063854 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA24_RS05530 (MUA24_05510)	1059420..1059890	+	471	Protein_1050	hypothetical protein	-
MUA24_RS05535 (MUA24_05515)	1060231..1060917	+	687	WP_001641381.1	thermonuclease family protein	-
MUA24_RS05540 (MUA24_05520)	1061274..1061474	+	201	WP_001059082.1	cold-shock protein	-
MUA24_RS05545 (MUA24_05525)	1061968..1062186	-	219	WP_000005884.1	hypothetical protein	-
MUA24_RS05550 (MUA24_05530)	1062248..1062532	-	285	WP_262534196.1	hypothetical protein	-
MUA24_RS05555 (MUA24_05535)	1062620..1063189	-	570	WP_262534198.1	lipoprotein N-acylation protein LnsA	-
MUA24_RS05560 (MUA24_05540)	1063377..1063565	-	189	WP_262521583.1	hypothetical protein	Toxin
MUA24_RS05565 (MUA24_05545)	1063594..1063854	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA24_RS05570 (MUA24_05550)	1064194..1064397	+	204	WP_153158483.1	sterile alpha motif-like domain-containing protein	-
MUA24_RS05575 (MUA24_05555)	1064394..1064630	-	237	WP_000368687.1	hypothetical protein	-
MUA24_RS05580 (MUA24_05560)	1064855..1065436	+	582	WP_262534200.1	histidine phosphatase family protein	-
MUA24_RS05585 (MUA24_05565)	1065509..1066126	-	618	WP_262534201.1	LysE/ArgO family amino acid transporter	-
MUA24_RS05590 (MUA24_05570)	1066282..1066776	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
MUA24_RS05595 (MUA24_05575)	1067175..1067597	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
MUA24_RS05600 (MUA24_05580)	1067745..1068461	+	717	WP_262534202.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	tsst-1 / vWbp	1036322..1070041	33719

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (8-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (21-69)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7158.81 Da
• Isoelectric Point: 9.9971

>T241332 WP_262521583.1 NZ_CP095109:c1063565-1063377 [Staphylococcus aureus]
MSLHFAILFWLSLIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T241332 NZ_LT991958:93348-94673 [Enterobacter cloacae complex sp.]
ATGAGCCGGAAACAGCAGCGTCTGGCAATCTGGATGAACGGAATCAAAGTCGGATACTGGGAAAAAAGTAAAGGGGTAGA
CAGCTTACAATACCTTCCTGACTGGAGTGCAGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTCCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTTCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACAGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGCGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGAACAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAAACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCATTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAAGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAGTTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCACTCTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT241332 WP_001059690.1 NZ_CP095109:c1063854-1063594 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT241332 NZ_LT991958:93050-93343 [Enterobacter cloacae complex sp.]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGTTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGGGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCTATCCTGGGCGTAAAAATCAGCTTCTCCTCGACAACCGCCTCTTCAGAGGGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGAAATGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VN56