Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 780697..781485 Replicon chromosome
Accession NZ_CP095109
Organism Staphylococcus aureus strain IVB6171

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA24_RS04030 Protein ID WP_262533931.1
Coordinates 780697..781158 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag MUA24_RS04035 Protein ID WP_000333630.1
Coordinates 781171..781485 (-) Length 105 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA24_RS04000 (MUA24_03985) 776321..776545 + 225 WP_000384171.1 hypothetical protein -
MUA24_RS04005 (MUA24_03990) 776822..777676 + 855 WP_262533924.1 N-acetylglucosaminidase -
MUA24_RS04010 (MUA24_03995) 777862..778899 - 1038 WP_262533926.1 site-specific integrase -
MUA24_RS04015 (MUA24_04000) 779402..779629 + 228 WP_262533927.1 hypothetical protein -
MUA24_RS04020 (MUA24_04005) 779827..780222 - 396 WP_001558060.1 hypothetical protein -
MUA24_RS04025 (MUA24_04010) 780250..780678 - 429 WP_262533929.1 hypothetical protein -
MUA24_RS04030 (MUA24_04015) 780697..781158 - 462 WP_262533931.1 toxin Toxin
MUA24_RS04035 (MUA24_04020) 781171..781485 - 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
MUA24_RS04040 (MUA24_04025) 781637..781873 + 237 WP_262533932.1 helix-turn-helix transcriptional regulator -
MUA24_RS04045 (MUA24_04030) 781887..782036 + 150 WP_262533934.1 hypothetical protein -
MUA24_RS04050 (MUA24_04035) 782090..782578 - 489 WP_262533935.1 hypothetical protein -
MUA24_RS04055 (MUA24_04040) 782638..783360 + 723 WP_262533936.1 BRO family protein -
MUA24_RS04060 (MUA24_04045) 783385..783594 + 210 WP_000455728.1 hypothetical protein -
MUA24_RS04065 (MUA24_04050) 783608..783775 + 168 WP_115118189.1 DUF1270 domain-containing protein -
MUA24_RS04070 (MUA24_04055) 783776..784096 + 321 WP_262533937.1 hypothetical protein -
MUA24_RS04075 (MUA24_04060) 784201..784503 + 303 WP_262533938.1 DUF2482 family protein -
MUA24_RS04080 (MUA24_04065) 784508..784768 + 261 WP_000291066.1 DUF1108 family protein -
MUA24_RS04085 (MUA24_04070) 784778..784999 + 222 WP_000815403.1 DUF2483 family protein -
MUA24_RS04090 (MUA24_04075) 784992..785615 + 624 WP_000139727.1 DUF1071 domain-containing protein -
MUA24_RS04095 (MUA24_04080) 785615..786040 + 426 WP_262533941.1 single-stranded DNA-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak 771734..822011 50277


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(4-62)


Sequences


Toxin        


Download         Length: 154 a.a.        Molecular weight: 18053.32 Da        Isoelectric Point: 4.9129

>T241329 WP_262533931.1 NZ_CP095109:c781158-780697 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGIFFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFTSAVPLHEIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Download         Length: 462 bp

>T241329 NZ_LT991957:c3230525-3230307 [Enterobacter cloacae complex sp.]
ATGTCTGATAAACCATTAACTAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACACTCGAGCGGGT
TATTGAGAAAAATAAATACGAGCTGTCCGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAAC
TGACCATGAATAAACTGTATGACAAGATCCCCACTTCGGTATGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT241329 WP_000333630.1 NZ_CP095109:c781485-781171 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT241329 NZ_LT991957:c3230927-3230553 [Enterobacter cloacae complex sp.]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTCGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTAAACGAGCTGATTGAGC
ATATCGCTACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References