Detailed information of TA system TA241326

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 707190..707966
• Replicon: chromosome
• Accession: NZ_CP095109
• Organism: Staphylococcus aureus strain IVB6171

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: MUA24_RS03580
• Protein ID: WP_000031108.1
• Coordinates: 707814..707966 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MUA24_RS03575
• Protein ID: WP_262533842.1
• Coordinates: 707190..707789 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA24_RS03555 (MUA24_03540)	703106..704563	+	1458	WP_262533840.1	ABC transporter permease subunit	-
MUA24_RS03560 (MUA24_03545)	704556..705278	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
MUA24_RS03565 (MUA24_03550)	705429..706556	+	1128	WP_262533841.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA24_RS03570 (MUA24_03555)	706561..707031	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA24_RS03575 (MUA24_03560)	707190..707789	+	600	WP_262533842.1	glucosamine-6-phosphate isomerase	Antitoxin
MUA24_RS03580 (MUA24_03565)	707814..707966	+	153	WP_000031108.1	SAS053 family protein	Toxin
MUA24_RS03585 (MUA24_03570)	708571..708966	+	396	WP_262533843.1	hypothetical protein	-
MUA24_RS03590 (MUA24_03575)	709162..710547	+	1386	WP_262533844.1	class II fumarate hydratase	-
MUA24_RS03595 (MUA24_03580)	711012..711833	-	822	WP_000669377.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T241326 WP_000031108.1 NZ_CP095109:707814-707966 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T241326 NZ_LT991957:2143225-2143539 [Enterobacter cloacae complex sp.]
ATGCATTTAATCTCAATGAAGGCAATTTGTGAGGCGGTAAGCCAGTTTCCACAATACAGGGATGAACTTCTCTTTTTGGG
AAGAGTTATCGAAAAAAGCCATTGCCCGACGCCTGCTGCGCTAAGAAAACTGTTTCCAACGCTGGATAACTTCAAGTATC
TCGATAAGCATTATGTTATTGATATTGCAAATAACAATCTCAGAGTAGTGGCTCTCATTTTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCAAAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22373.50 Da
• Isoelectric Point: 5.1445

>AT241326 WP_262533842.1 NZ_CP095109:707190-707789 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGTNKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT241326 NZ_LT991957:2143536-2143955 [Enterobacter cloacae complex sp.]
ATGATGATCGTTGCTGATGCACTAAAAGCTACGCATGACCTTGTTGCGGCTGTTCCTCTGCTGGGTGAACATCCTAACGA
GAAGGATTACCAGGACGCACTTGAGCTGGTTGAGTATCTGCTCATGCATGAACCTGGCAGCCCTTTACTGGATATTGTAT
GTGCGAGAATCAGCCGCTACGAAGCAAACCGGCCTGAAATTGTCGCGCTACGCCAGGAGATGGAATCTGTTCCCGTGGGG
ATTGCGGTGTTAAGAACGCTTATGGATCAGCACAAACTCACTATTTCGGATTTTCAGGACGAAATAGGTAGTAAATCAAT
GGTTTCAAGGGTACTCAATGGGCAGCGTCAGCTCACACTGAACCATATAAAAAAACTGGCGGCCCGCTTTGGCGTTTCGC
CTGCGCTGTTTATTGAGTGA

Structures

Toxin

• AlphaFold DB: X5E2E6