241325

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1131392..1132195 Replicon chromosome
Accession NZ_CP095107
Organism Staphylococcus delphini strain IVB6226

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA63_RS05535 Protein ID WP_262604814.1
Coordinates 1131392..1131853 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA63_RS05540 Protein ID WP_262604815.1
Coordinates 1131866..1132195 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA63_RS05515 (MUA63_05505) 1127525..1128508 - 984 WP_262616054.1 DUF3644 domain-containing protein -
MUA63_RS05520 1128676..1128858 - 183 WP_262616053.1 hypothetical protein -
MUA63_RS05525 (MUA63_05510) 1129889..1130146 - 258 WP_262620243.1 FlgT C-terminal domain-containing protein -
MUA63_RS05530 (MUA63_05515) 1130452..1131351 - 900 WP_262620244.1 HIRAN domain-containing protein -
MUA63_RS05535 (MUA63_05520) 1131392..1131853 - 462 WP_262604814.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUA63_RS05540 (MUA63_05525) 1131866..1132195 - 330 WP_262604815.1 helix-turn-helix transcriptional regulator Antitoxin
MUA63_RS05545 (MUA63_05530) 1132395..1132640 + 246 WP_096543105.1 helix-turn-helix transcriptional regulator -
MUA63_RS05550 (MUA63_05535) 1132655..1133410 + 756 WP_262604816.1 phage antirepressor KilAC domain-containing protein -
MUA63_RS05555 (MUA63_05540) 1133425..1133649 + 225 WP_262586880.1 hypothetical protein -
MUA63_RS05560 (MUA63_05545) 1133652..1133828 - 177 WP_194746656.1 hypothetical protein -
MUA63_RS05565 (MUA63_05550) 1133913..1134356 + 444 WP_262619832.1 hypothetical protein -
MUA63_RS05570 (MUA63_05555) 1134369..1134563 + 195 WP_262619831.1 hypothetical protein -
MUA63_RS05575 (MUA63_05560) 1134686..1134883 + 198 WP_262616156.1 hypothetical protein -
MUA63_RS05580 (MUA63_05565) 1134870..1135250 - 381 WP_262616045.1 DUF2513 domain-containing protein -
MUA63_RS05585 (MUA63_05570) 1135341..1135482 + 142 Protein_1063 hypothetical protein -
MUA63_RS05590 (MUA63_05575) 1135475..1135684 - 210 WP_262612040.1 hypothetical protein -
MUA63_RS05595 (MUA63_05580) 1135754..1135984 + 231 WP_262612041.1 hypothetical protein -
MUA63_RS05600 (MUA63_05585) 1135986..1136195 + 210 WP_262619830.1 hypothetical protein -
MUA63_RS05605 (MUA63_05590) 1136465..1136725 + 261 WP_262619829.1 DUF1108 family protein -
MUA63_RS05610 (MUA63_05595) 1136737..1136955 + 219 WP_262612044.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA 1107519..1203522 96003


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(17-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18136.70 Da        Isoelectric Point: 5.9343

>T241325 WP_262604814.1 NZ_CP095107:c1131853-1131392 [Staphylococcus delphini]
MGLYEETLIQHDYIDVREANVLPDDLDGVWLGDLILIKRNLPEKKKVEVLFEELAHHKLTYGDITNQKQFNNRKFENYAR
RYSYEKSMPLSGIVQAFEQGVHNLYELANFFEISEGHVLDCIEHYKKKYGLQVKYGKYLIRFEPLTIYKDLAD

Download         Length: 462 bp

>T241325 NZ_LT991957:c2028582-2028211 [Enterobacter cloacae complex sp.]
ATGGAACACATGGCAGTGTTTGATACCAATATTCTCATCGATCTCTTTAACAATCACGTAGAAGCTGCCGATACGATCGA
TCGTACGGCCTCGCATCGGGCGATTAGCCTTATCACGTGGATGGAGGTCATGGTCGGCGCGCGCAGGCATGGTCATGAAG
CGAAAACGGCTGCTGTCATGGGCGCTTTTGAAATTATCGACGTTTCGCGGGATATCGCTGAAAGAAGCGTTGTGCTCCGT
GAGAAACACGGGATGAAACTACCTGATGCCATCATTTTGGCCACAGCCCAGAGCAGAAATTGTCCCCTGGTGTCCCGCAA
TACCAAAGACTTTGCCGGAATAGCCGGGGTTGTTTCCCCTTACCAGCTGTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12712.40 Da        Isoelectric Point: 9.3985

>AT241325 WP_262604815.1 NZ_CP095107:c1132195-1131866 [Staphylococcus delphini]
MRNNDEIITIIKASMKKQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQEQPQH
RAAHLEGELTDEEWQRVLDYADYIRSKRK

Download         Length: 330 bp

>AT241325 NZ_LT991957:c2028827-2028585 [Enterobacter cloacae complex sp.]
ATGAGTCTTTTGGCGGATTTTGAGATGGGCAGAATACTGATTGATTTGTCTGATGACGTAATTCAACGGCTGGATAACCT
GAAGCAGCTGCGTAACCAGCCCCGCGCCGAATTGCTTCGTGAAGCCATTGAACAATATCTCGATCAGCAGAGTTCTTCGG
TAATTCGTGATGCGCTTGGTTTGTGGGGAAATCAGCAAGAAGATGGGCTGGAGTACGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References