Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 916108..916632 Replicon chromosome
Accession NZ_CP095107
Organism Staphylococcus delphini strain IVB6226

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag MUA63_RS04315 Protein ID WP_014613379.1
Coordinates 916279..916632 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag MUA63_RS04310 Protein ID WP_014613378.1
Coordinates 916108..916278 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA63_RS04285 (MUA63_04275) 911998..912471 + 474 WP_096597952.1 PH domain-containing protein -
MUA63_RS04290 (MUA63_04280) 912464..913993 + 1530 WP_262611919.1 PH domain-containing protein -
MUA63_RS04295 (MUA63_04285) 913977..914495 + 519 WP_262611920.1 PH domain-containing protein -
MUA63_RS04300 (MUA63_04290) 914492..914842 + 351 WP_262611921.1 holo-ACP synthase -
MUA63_RS04305 (MUA63_04295) 914876..916024 + 1149 WP_262611922.1 alanine racemase -
MUA63_RS04310 (MUA63_04300) 916108..916278 + 171 WP_014613378.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA63_RS04315 (MUA63_04305) 916279..916632 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA63_RS04320 (MUA63_04310) 916690..917694 + 1005 WP_262611923.1 PP2C family protein-serine/threonine phosphatase -
MUA63_RS04325 (MUA63_04315) 917773..918099 + 327 WP_096597944.1 anti-sigma factor antagonist -
MUA63_RS04330 (MUA63_04320) 918099..918578 + 480 WP_262611924.1 anti-sigma B factor RsbW -
MUA63_RS04335 (MUA63_04325) 918553..919323 + 771 WP_019165834.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T241324 WP_014613379.1 NZ_CP095107:916279-916632 [Staphylococcus delphini]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T241324 NZ_LT991957:c1905828-1905643 [Enterobacter cloacae complex sp.]
GTGAAAAGTGCGGATATCATTACTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGATTGGTTACCGTCCCACATCCTAAAAAGGACATTAAACCAGGCACTCTCGCACAAATCT
GGCGACAGGCGGGAATTAAACACTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT241324 WP_014613378.1 NZ_CP095107:916108-916278 [Staphylococcus delphini]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT241324 NZ_LT991957:c1905628-1905224 [Enterobacter cloacae complex sp.]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGTGGTTTCTTTCCTGACGTTCCGGGGTGTTTTTT
TGCGGGGGATTCACTGGATGATGCTTTTCAGGACGCACGTGATGCATTAACTGCCCATTTTGAAGCGTTGTTTGAAATGG
ATGAAATGTTGCCATTTCCGGGTATGGTTGAAGCGCATCTGGCAAGTCATCCGGAGGATTTCATTGGCGGACAATGGTTG
CTGGTGGATATCAATATGAAACAGTTTGAAGGCAAAGTAGAGCGCATCAATATTACGATACCTCGCCGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCACAATTTACTAACCGAAGTGCTTTTCTTGCAGAGGCAGCACGGCGTGTACTGC
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References