Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 901368..901889 Replicon chromosome
Accession NZ_CP095107
Organism Staphylococcus delphini strain IVB6226

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MUA63_RS04240 Protein ID WP_262611912.1
Coordinates 901668..901889 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MUA63_RS04235 Protein ID WP_262611911.1
Coordinates 901368..901655 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA63_RS04210 (MUA63_04200) 896629..897432 + 804 WP_262611909.1 hydroxyethylthiazole kinase -
MUA63_RS04215 (MUA63_04205) 897422..898060 + 639 WP_096649784.1 thiamine phosphate synthase -
MUA63_RS04220 (MUA63_04210) 898149..899015 + 867 WP_096543018.1 membrane protein insertase YidC -
MUA63_RS04225 (MUA63_04215) 899069..899725 - 657 WP_262611910.1 HD domain-containing protein -
MUA63_RS04230 (MUA63_04220) 899746..901236 - 1491 WP_096597966.1 cardiolipin synthase -
MUA63_RS04235 (MUA63_04225) 901368..901655 + 288 WP_262611911.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA63_RS04240 (MUA63_04230) 901668..901889 + 222 WP_262611912.1 heavy metal-associated domain-containing protein Toxin
MUA63_RS04245 (MUA63_04235) 901893..902099 + 207 WP_262611913.1 cation transporter -
MUA63_RS04250 (MUA63_04240) 902200..904380 + 2181 WP_262611914.1 heavy metal translocating P-type ATPase -
MUA63_RS04255 (MUA63_04245) 904466..904612 + 147 WP_014613367.1 Lmo0850 family protein -
MUA63_RS04260 (MUA63_04250) 905377..906138 + 762 WP_262611915.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(12-90)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8133.21 Da        Isoelectric Point: 4.1528

>T241323 WP_262611912.1 NZ_CP095107:901668-901889 [Staphylococcus delphini]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVVIDLATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSYKGV

Download         Length: 222 bp

>T241323 NZ_LT991957:c1132447-1132037 [Enterobacter cloacae complex sp.]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCGTTACTGCTCCACGGACTGGTCGCGGC
ATTGGTGTTACTGGTGCCGTGGCCGCTTAGCTACACCCCTCTGTGGTTGCTTTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGAAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATAGGGACGCCGTGGATGCTCAATACCGGGATGATGCTACGGCTGCGTCGGGTTGAGGACAATCGACG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATGCCGCGGAGTGGCGGGATCTGCGCCGGCTCATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11001.60 Da        Isoelectric Point: 6.4854

>AT241323 WP_262611911.1 NZ_CP095107:901368-901655 [Staphylococcus delphini]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALDSVASRLLDHHMKGCIMHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT241323 NZ_LT991957:c1132694-1132428 [Enterobacter cloacae complex sp.]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTTGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGTCTGTTTGTCCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References