Detailed information of TA system TA241321

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1800711..1801225
• Replicon: chromosome
• Accession: NZ_CP095104
• Organism: Staphylococcus simulans strain IVB6179

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MUA12_RS09185
• Protein ID: WP_031262808.1
• Coordinates: 1800711..1801061 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A2T4QNU3
• Locus tag: MUA12_RS09190
• Protein ID: WP_023016097.1
• Coordinates: 1801058..1801225 (-)
• Length: 56 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA12_RS09165 (MUA12_09120)	1797790..1798560	-	771	WP_002481747.1	RNA polymerase sigma factor SigB	-
MUA12_RS09170 (MUA12_09125)	1798535..1799014	-	480	WP_023016096.1	anti-sigma B factor RsbW	-
MUA12_RS09175 (MUA12_09130)	1799016..1799342	-	327	WP_002481749.1	anti-sigma factor antagonist	-
MUA12_RS09180 (MUA12_09135)	1799418..1800419	-	1002	WP_002481750.1	SpoIIE family protein phosphatase	-
MUA12_RS09185 (MUA12_09140)	1800711..1801061	-	351	WP_031262808.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MUA12_RS09190 (MUA12_09145)	1801058..1801225	-	168	WP_023016097.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
MUA12_RS09195 (MUA12_09150)	1801306..1802460	-	1155	WP_023016098.1	alanine racemase	-
MUA12_RS09200 (MUA12_09155)	1802540..1802893	-	354	WP_031262810.1	holo-ACP synthase	-
MUA12_RS09205 (MUA12_09160)	1802895..1803392	-	498	WP_060804061.1	PH domain-containing protein	-
MUA12_RS09210 (MUA12_09165)	1803385..1804878	-	1494	WP_262577153.1	PH domain-containing protein	-
MUA12_RS09215 (MUA12_09170)	1804871..1805335	-	465	WP_107547573.1	PH domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12976.09 Da
• Isoelectric Point: 10.0474

>T241321 WP_031262808.1 NZ_CP095104:c1801061-1800711 [Staphylococcus simulans]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIGISLGLTHKN

Nucleotide

• Length: 351 bp

>T241321 NZ_LT991956:c182433-181948 [Enterobacter hormaechei subsp. steigerwaltii]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin

Protein

• Length: 56 a.a.
• Molecular weight: 6257.78 Da
• Isoelectric Point: 3.6836

>AT241321 WP_023016097.1 NZ_CP095104:c1801225-1801058 [Staphylococcus simulans]
MSTFNQNRSYSLEQSLKEGYSQMADLNLSLATEAFSVECEACDCNESYLTFDKDE

Nucleotide

• Length: 168 bp

>AT241321 NZ_LT991956:c182687-182421 [Enterobacter hormaechei subsp. steigerwaltii]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2T4QNU3