Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3008837..3009669 Replicon chromosome
Accession NC_012967
Organism Escherichia coli B str. REL606

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P5UBZ5
Locus tag ECB_RS14850 Protein ID WP_001094454.1
Coordinates 3009295..3009669 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3G8RJV8
Locus tag ECB_RS14845 Protein ID WP_001320394.1
Coordinates 3008837..3009205 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECB_RS14810 3005124..3005579 + 456 WP_000581493.1 hypothetical protein -
ECB_RS14815 3005658..3005891 + 234 WP_001119719.1 DUF905 family protein -
ECB_RS14820 3005991..3006809 + 819 WP_001234644.1 DUF945 domain-containing protein -
ECB_RS14825 3006864..3007349 + 486 WP_000849578.1 antirestriction protein -
ECB_RS14830 3007365..3007841 + 477 WP_001347688.1 RadC family protein -
ECB_RS14835 3007904..3008125 + 222 WP_000692300.1 DUF987 domain-containing protein -
ECB_RS14840 3008144..3008787 + 644 Protein_2843 antitoxin of toxin-antitoxin stability system -
ECB_RS14845 3008837..3009205 + 369 WP_001320394.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECB_RS14850 3009295..3009669 + 375 WP_001094454.1 TA system toxin CbtA family protein Toxin
ECB_RS14855 3009666..3010154 + 489 WP_000777545.1 hypothetical protein -
ECB_RS14860 3010166..3010363 + 198 WP_000839276.1 DUF957 domain-containing protein -
ECB_RS14865 3010460..3011029 + 570 WP_001290250.1 DUF4942 domain-containing protein -
ECB_RS14870 3011372..3011542 + 171 Protein_2849 IS110 family transposase -
ECB_RS14875 3012353..3013336 + 984 WP_024181915.1 KpsF/GutQ family sugar-phosphate isomerase -
ECB_RS14880 3013408..3014556 + 1149 WP_000905931.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14059.10 Da        Isoelectric Point: 9.2447

>T24132 WP_001094454.1 NC_012967:3009295-3009669 [Escherichia coli B str. REL606]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T24132 NC_012967:3009295-3009669 [Escherichia coli B str. REL606]
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13623.22 Da        Isoelectric Point: 6.4783

>AT24132 WP_001320394.1 NC_012967:3008837-3009205 [Escherichia coli B str. REL606]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT24132 NC_012967:3008837-3009205 [Escherichia coli B str. REL606]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P5UBZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8RJV8

References