241318

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 973032..973546 Replicon chromosome
Accession NZ_CP095102
Organism Staphylococcus simulans strain IVB6188

Toxin (Protein)


Gene name TsdT Uniprot ID A0A133QQ97
Locus tag MUA56_RS04320 Protein ID WP_002481764.1
Coordinates 973340..973546 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A133QQA1
Locus tag MUA56_RS04315 Protein ID WP_002481765.1
Coordinates 973032..973325 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA56_RS04290 (MUA56_04295) 968427..969065 + 639 WP_023016110.1 thiamine phosphate synthase -
MUA56_RS04295 (MUA56_04300) 969154..970023 + 870 WP_002481769.1 membrane protein insertase YidC -
MUA56_RS04300 (MUA56_04305) 970149..970661 + 513 WP_002481768.1 GNAT family N-acetyltransferase -
MUA56_RS04305 (MUA56_04310) 970718..971368 - 651 WP_060804054.1 HD domain-containing protein -
MUA56_RS04310 (MUA56_04315) 971392..972873 - 1482 WP_002481766.1 cardiolipin synthase -
MUA56_RS04315 (MUA56_04320) 973032..973325 + 294 WP_002481765.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA56_RS04320 (MUA56_04325) 973340..973546 + 207 WP_002481764.1 heavy metal-associated domain-containing protein Toxin
MUA56_RS04325 (MUA56_04330) 973565..973771 + 207 WP_002481763.1 copper ion binding protein -
MUA56_RS04330 (MUA56_04335) 973864..976056 + 2193 WP_119564154.1 heavy metal translocating P-type ATPase -
MUA56_RS04335 (MUA56_04340) 976138..976278 + 141 WP_023016106.1 Lmo0850 family protein -
MUA56_RS04340 (MUA56_04345) 976338..977546 - 1209 WP_002481760.1 FtsW/RodA/SpoVE family cell cycle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-65)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7861.82 Da        Isoelectric Point: 4.2670

>T241318 WP_002481764.1 NZ_CP095102:973340-973546 [Staphylococcus simulans]
MHSSVIQISGMETEEQQHILQEHLQQMIGMSEVQVDLKSQEVKASYQTPISLNNLEKEIYDQGYQILN

Download         Length: 207 bp

>T241318 NZ_LT991956:92610-93095 [Enterobacter hormaechei subsp. steigerwaltii]
GTGGGACGTGTAACAGTACCAGAACCTTTATCCAGCTTTCATCAGGTGGCGGAATTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAGGCCTCAAAAACCAGGCTCTCGGATCGGCCAGAACGTTTGTAGTGTGTAAAAAAGACACGA
AACAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCCGATCCCATCCCTGTTATTATACTTGCCCGTCTTGCTGTCGATCTCTCTTTCCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTCACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCAACGGACATTATTTCTTAAACTCCCT
CAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11033.69 Da        Isoelectric Point: 6.9688

>AT241318 WP_002481765.1 NZ_CP095102:973032-973325 [Staphylococcus simulans]
MTQEERAHHSEKIKSNLKARLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVAVKLLDHHMKGCILHKAEDGQA
EAAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT241318 NZ_LT991956:92356-92622 [Enterobacter hormaechei subsp. steigerwaltii]
ATGAAATCAGATGTTCAACTTAATCTTAGAGCAAAGGAATCACAGCGGGCGCTCATTGATGCTGCTGCGGAAATTCTTCA
CAAATCACGAACAGACTTCATCCTGGAAATGGCCTGTCAGGCCGCTGAGAACGTGATCCTCGATCGCCGGGTCTTTAATT
TTAACGATGAACAATATGCCGAATTCATCGACATGCTTGATGCCCCTGTTGCAGATGATCCTGCCATAGATAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133QQ97

Antitoxin

Source ID Structure
AlphaFold DB A0A133QQA1

References